Current Highlight from January 22, 2016
Effects of Silver Nanoparticles on Accumulation, Distribution, and Toxicity
NCTR scientists conducted a 13-week study in rats to determine the differential accumulation, distribution, and potential toxicity of silver nanoparticles (AgNPs) administered daily by mouth. Significant AgNP accumulations in tissues and organs were observed to be both dose- and size-dependent. Additionally, sex differences were noted with female rats having significantly higher accumulations than males in the kidney, liver, jejunum, and colon. No significant changes in body weight or food/water intake and no treatment-related histopathological results were identified. AgNPs are widely used in consumer products and their use in the food industry has raised public concern related to safety, toxicity, and health risks. These studies were conducted at NCTR under the auspices and funding of the Interagency Agreement between the Food and Drug Administration (FDA)/NCTR and the National Institute of Environmental Health Sciences/National Toxicology Program. A manuscript describing the study is available online at Toxicological Sciences
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.For additional information, please contact Mary Boudreau, Ph.D., Division of Biochemical Toxicology, FDA/NCTR.
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