Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up s... - PubMed - NCBI
Psychiatry Res. 2015 Dec 11. pii: S0165-1781(15)30452-2. doi: 10.1016/j.psychres.2015.12.011. [Epub ahead of print]
Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.
Watanabe Y1,
Nunokawa A2,
Shibuya M3,
Ikeda M4,
Hishimoto A5,
Kondo K4,
Egawa J3,
Kaneko N2,
Muratake T6,
Saito T4,
Okazaki S5,
Shimasaki A4,
Igeta H3,
Inoue E3,
Hoya S3,
Sugai T3,
Sora I5,
Iwata N4,
Someya T3.
Abstract
Rare inherited variations in multiplex families with schizophrenia are suggested to play a role in the genetic etiology of schizophrenia. To further investigate the role of rare inherited variations, we performed whole-exome sequencing (WES) in three families, each with two affected siblings. We also performed a three-stage follow-up case-control study in a Japanese population with a total of 2617 patients and 2396 controls. WES identified 15 rare truncating variations that were variously present in the two affected siblings in each family. These variations did not necessarily segregate with schizophrenia within families, and they were different in each family. In the follow-up study, four variations (NWD1 W169X, LCORL R7fsX53, CAMK2B L497fsX497, and C9orf89 Q102X) had a higher mutant allele frequency in patients compared with controls, although these associations were not significant in the combined population, which comprised the first-, second- and third-stage populations. These results do not support a contribution of the rare truncating variations identified in the three families to the genetic etiology of schizophrenia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
KEYWORDS:
Affected siblings; Case-control study; Rare truncating variations; Schizophrenia; Whole-exome sequencing
- PMID:
- 26706132
- [PubMed - as supplied by publisher]
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