S-Adenosyl-L-methionine, also called SAMe or SAM-e, is a chemical found naturally in the body. SAMe is sold in the United States as a dietary supplement.
Early research showed SAMe is involved in a variety of body functions, especially in the brain and the liver. These findings prompted researchers to investigate the possible value of SAMe in the treatment of mental illnesses and liver diseases. During clinical trials in people with depression, some study participants who also had osteoarthritis reported that their joint symptoms improved when they were taking SAMe.
This fact sheet provides basic information about SAMe, summarizes scientific research on safety and effectiveness, and suggests sources for additional information. Seehttp://1.usa.gov/1RNwBVg.
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