Prion Disease: Genomics and Public Health || Public Health Genomics Knowledge Base (v1.0)

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Prion Disease: Genomics and Public Health

What's New

Last Updated: Jan 21, 2016

• Prion Diseases
  A family of rare progressive neurodegenerative disorders that affect both humans and animals.(From CDC Information Database)
• Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy.
  Manix Marc et al. Neurosurgical focus 2015 Nov (5) E2 (From Discoveries and Insights Database)
• Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.
  Crowell Jenna et al. Journal of virology 2015 Oct (20) 10427-41 (From Discoveries and Insights Database)
• Prion Disease Induces Alzheimer Disease-Like Neuropathologic Changes.
  Tousseyn Thomas et al. Journal of neuropathology and experimental neurology 2015 Sep (9) 873-88(From Discoveries and Insights Database)
• "Big Data" Gets Personal
  MS Lebo, et al, Science Translational Medicine, January 20, 2016 (From Discoveries and Insights Database)
• Quantifying prion disease penetrance using large population control cohorts
  Minikel EV, et al. Science Translational Medicine 20 Jan 2016: Vol. 8, Issue 322, pp. 322ra9 (FromGenomics & Health Impact Scan Database)
• Does this mean I'll definitely get the disease?
  Eric Vallabh Minikel blog post, January 20, 2016 (From Discoveries and Insights Database)
• Ovine leukocyte profiles do not associate with variation in the prion gene, but are breed dependent.
  Mousel Michelle R, et al. Animal genetics 2015 12 (From HuGE Literature Finder)
• Prion protein gene sequence and chronic wasting disease susceptibility in white-tailed deer (Odocoileus virginianus).
  Brandt Adam L, et al. Prion 2015 12 0 (From HuGE Literature Finder)
• Evaluating pathogenic dementia variants in posterior cortical atrophy.
  Carrasquillo Minerva M, et al. Neurobiology of aging 2015 10 (From HuGE Literature Finder)
• Sporadic Creutzfeldt-Jakob Disease: Prion Pathology in Medulla Oblongata-Possible Routes of Infection and Host Susceptibility.
  Iacono Diego, et al. BioMed research international 2015 0 396791 (From HuGE Literature Finder)
• Inherited mtDNA variations are not strong risk factors in human prion disease.
  Hudson Gavin, et al. Neurobiology of aging 2015 10 (10) 2908.e1-3 (From HuGE Literature Finder)
• R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
  Slattery Catherine F, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014 11 (6) 602-608.e4 (From HuGE Literature Finder)
• Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease.
  Sassi Celeste, et al. Neurobiology of aging 2014 12 (12) 2881.e1-6 (From HuGE Literature Finder)
• Human prion protein sequence elements impede cross-species chronic wasting disease transmission.
  Kurt Timothy D, Jiang Lin, Fernández-Borges Natalia, Bett Cyrus, Liu Jun, Yang Tom, Spraker Terry R, Castilla Joaquín, Eisenberg David, Kong Qingzhong, Sigurdson Christina J.J. Clin. Invest. 2015 Apr (4) 1485-96 (From Advanced Molecular Detection Clips Database)
• Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone.
  Cali Ignazio et al. Acta Neuropathol Commun 2015 3(1) 37 (From CDC-Authored Genomics Publication Database)
• A naturally occurring variant of the human prion protein completely prevents prion disease.
  Asante Emmanuel A, Smidak Michelle, Grimshaw Andrew, Houghton Richard, Tomlinson Andrew, Jeelani Asif, Jakubcova Tatiana, Hamdan Shyma, Richard-Londt Angela, Linehan Jacqueline M, Brandner Sebastian, Alpers Michael, Whitfield Jerome, Mead Simon, Wadsworth Jonathan D F, Collinge John.Nature 2015 Jun 10. (From Advanced Molecular Detection Clips Database)
• The influence of PRNP polymorphisms on human prion disease susceptibility: an update.
  Kobayashi Atsushi, et al. Acta neuropathologica 2015 8 (2) 159-70 (From HuGE Literature Finder)