domingo, 5 de octubre de 2014

PayPerView: DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics - Karger Publishers

PayPerView: DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics - Karger Publishers



Tools and Databases



Public Health Genomics
(DOI:10.1159/000365895)

DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics

Dalabira E. · Viennas E. · Daki E. · Komianou A. · Bartsakoulia M. · Poulas K. · Katsila T. · Tzimas G. ·Patrinos G.P. 
Departments of aPharmacy, School of Health Sciences and bComputer Engineering and Informatics, Faculty of Engineering, University of Patras, and cDepartment of Computer and Informatics Engineering, Technological Educational Institute of Western Greece, Patras, Greece


Abstract

Background/Aims: Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels - approved by regulatory agencies - and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists.Methods: We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics. Results and Conclusions: A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases. © 2014 S. Karger AG, Basel

No hay comentarios:

Publicar un comentario