Discovery of modulators of HIV-1 infection from the human peptidome : Nature Reviews Microbiology : Nature Publishing Group

Discovery of modulators of HIV-1 infection from the human peptidome : Nature Reviews Microbiology : Nature Publishing Group

Figure 2: Endogenous peptides that affect HIV-1 infection.

Overview of the HIV-1 entry steps that are targeted by peptides. Amyloidogenic peptides that are derived from human semen, such as fragments of prostatic acidic phosphatase (PAP), can self-assemble into amyloid fibrils that promote the…

Discovery of modulators of HIV-1 infection from the human peptidome

• Jan Münch,
• Ludger Ständker,
• Wolf-Georg Forssmann
• & Frank Kirchhoff

• Affiliations
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Nature Reviews Microbiology

 

12,

 

715–722

 

(2014)

 

doi:10.1038/nrmicro3312

Published online

 

11 August 2014

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Abstract

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Almost all human proteins are subject to proteolytic degradation, which produces a broad range of peptides that have highly specific and sometimes unexpected functions. Peptide libraries that have been generated from human bodily fluids or tissues are a rich but mostly unexplored source of bioactive compounds that could be used to develop antimicrobial and immunomodulatory therapeutic agents. In this Innovation article, we describe the discovery, optimization and application of endogenous bioactive peptides from human-derived peptide libraries, with a particular focus on the isolation of endogenous inhibitors and promoters of HIV-1 infection.