lunes, 13 de octubre de 2014

A defining decade in DNA sequencing : Nature Methods : Nature Publishing Group

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A defining decade in DNA sequencing : Nature Methods : Nature Publishing Group





A defining decade in DNA sequencing

Nature Methods
 
11,
 
1003–1005
 
 
doi:10.1038/nmeth.3106
Published online
 
A revolution in DNA sequencing technology has enabled new insights from thousands of genomes sequenced across taxa.
The tenth anniversary of Nature Methods offers an excellent occasion to reflect on protocols and technologies that are rapidly shaping research methodology. A major advance has undoubtedly been the massive increase in DNA and RNA sequencing capabilities that fall under the general term of next-generation sequencing (NGS). The death in 2013 of Frederick Sanger, who pioneered methods for deciphering amino acid and nucleic acid sequences, for which he was awarded two Nobel Prizes (1958 and 1980), also affords the opportunity to look back at recent events and the extraordinary progress that has come from the sequencing metamorphosis. Many new sequencing platforms have matured while others have failed to gain a market share, but the result has been an extraordinary increase in sequencing capabilities (Fig. 1).


Figure 1: Sequencing technologies are evolving, with many platforms now reaching maturity as a few others have failed or are being phased out.
Sequencing technologies are evolving, with many platforms now reaching maturity as a few others have failed or are being phased out.

The future face of sequencing is unclear, but a bountiful sequencing capacity is assured for the future.
Marina Corral Spence/Nature Publishing Group

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