Novel Influenza A(H7N2) Virus in Chickens, Jilin Province, China, 2014 - Volume 20, Number 10—October 2014 - Emerging Infectious Disease journal - CDC

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Novel Influenza A(H7N2) Virus in Chickens, Jilin Province, China, 2014 - Volume 20, Number 10—October 2014 - Emerging Infectious Disease journal - CDC

Volume 20, Number 10—October 2014

Dispatch

Novel Influenza A(H7N2) Virus in Chickens, Jilin Province, China, 2014

On This Page

• The Study
• Conclusions
• Suggested Citation

Figures

• Figure 1
• Figure 2

Tables

• Table

Technical Appendicies

• Technical Appendix

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Jianzhong Shi, Guohua Deng, Xianying Zeng, Huihui Kong, Xiaoyu Wang, Kunpeng Lu, Xiurong Wang, Guodong Mu, Xiaolong Xu, Pengfei Cui, Hongmei Bao, Guobin Tian, and Hualan Chen 

Author affiliations: State Key Laboratory of Veterinary Biotechnology–Harbin Veterinary Research Institute, Harbin, China (J. Shi, G. Deng, X. Zeng, H. Kong, K. Lu, X. Wang, X. Xu, P. Cui, H. Bao, G. Tian, H. Chen); Jilin Province Center for Animal Disease Control and Prevention, Changchun, China (X. Wang, G. Mu)

Suggested citation for this article

Abstract

In February 2014, while investigating the source of a human infection with influenza A(H7N9) virus in northern China, we isolated subtypes H7N2 and H9N2 viruses from chickens on the patient’s farm. Sequence analysis revealed that the H7N2 virus is a novel reassortant of H7N9 and H9N2 viruses. Continued surveillance is needed.

Influenza subtype H7 viruses have been detected in poultry worldwide; associated human disease ranges from mild to severe (1–8). Human infections with influenza A(H7N9) viruses were first identified in China in March 2013 (9). As of March 11, 2014, a total of 375 laboratory-confirmed cases of human infection with influenza A(H7N9) virus, including 115 deaths, had been reported to the World Health Organization (10).

On February 21, 2014, the National Health and Family Planning Commission of China notified the World Health Organization of a laboratory-confirmed case of human infection with influenza virus subtype H7N9 (11). The patient was a 50-year-old farmer who lived in Jilin Province and traded chickens for a living. He became ill on February 15 and was confirmed to be infected with H7N9 virus on February 21. He recovered 2 weeks later. Although H7N9 viruses had been detected in live poultry markets in 12 provinces in China (12,13), the virus had not been detected in Jilin Province, in poultry or humans. To locate the origin of the infection, we conducted influenza virus surveillance among poultry in the patient’s village.

Dr Shi is a veterinary epidemiologist at the Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China. His research focuses on the surveillance, diagnostic, and molecular epidemiology of avian influenza viruses.

Acknowledgment

This study was supported by the Ministry of Science and Technology (KJYJ-2013-01-01,KJYJ-2013-01-01-02, and 2012ZX10004214), and by the China Agriculture Research System (CARS-42-G08), and by Ningxia Science and Technology Department (2013ZZN30).

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Figures

• Figure 1. Replication and virulence of avian influenza A virus subtypes H7N2 and H7N9 in mice. A) Virus titers in organs of mice. The data shown are the mean ± SD...
• Figure 2. Antibody titers in chicken serum against H7 influenza viruses. The hemagglutination inhibition (HI) antibody titers of the serum against the H7N2 virus A/chicken/Jilin/SD020/2014(H7N2) (A) and the H7N9 virus A/pigeon/Shanghai/S1069/2013...

Table

• Table. Homology among influenza viruses closely related to avian influenza virus A/chicken/Jilin/SD020/2014(H7N2) from Jilin, China, 2014

Technical Appendix

• Technical Appendix. Phylogenetic trees of avian influenza A(H7N2) virus. The tree topology was evaluated by 1,000-bootstrap analyses. The trees of H7 hemagglutinin (A), polymerase basic 2 (C), polymerase basic 1 (D),... 511 KB

Suggested citation for this article: Shi J, Deng G, Zeng X, Kong H, Wang X, Lu K, et al. Novel influenza A(H7N2) virus in chickens, Jilin Province, China, 2014. Emerg Infect Dis [Internet]. 2014 Oct [date cited]. http://dx.doi.org/10.3201/eid2010.140869

DOI: 10.3201/eid2010.140869