Genet Med. 2014 Sep 18. doi: 10.1038/gim.2014.125. [Epub ahead of print]
Disparities in uptake of BRCA1/2 genetic testing in a randomized trial of telephone counseling.
Butrick M1, Kelly S2, Peshkin BN2, Luta G3, Nusbaum R2, Hooker GW4, Graves K2, Feeley L2, Isaacs C2, Valdimarsdottir HB5, Jandorf L5, DeMarco T2, Wood M6, McKinnon W6, Garber J7, McCormick SR7, Schwartz MD2.
Purpose:As genetic counseling and testing become more fully integrated into clinical care, alternative delivery models are increasingly prominent. This study examines predictors of genetic testing for hereditary breast/ovarian cancer among high-risk women in a randomized trial of in-person versus telephone-based genetic counseling.Methods:Methods include multivariable logistic regression and interaction analyses.Results:Of the 669 participants, 600 completed counseling and 523 received test results. As previously reported, participants randomized to telephone counseling were significantly less likely to be tested. In intention-to-treat analyses, completion of counseling and testing was associated with: race/ethnicity (odds ratio (OR) = 1.96, 95% confidence interval (CI): 1.20-3.20), perceived stress (OR = 0.89, 95% CI: 0.81-0.98), knowledge (OR = 1.12, 95% CI: 1.02-1.23), and randomization group (OR = 1.48, 95% CI: 1.01-2.16). Further, race/ethnicity moderated the association between randomization group and testing; minority women receiving telephone counseling were least likely to complete testing.Conclusion:Evidence for logistical and communication-based explanations for this interaction is presented. The overall increased access made possible with telephone genetic counseling should be considered in light of the possibility that this may also lead to lower rates of testing among high-risk minority women. Additional care should be taken to assess and address potential barriers when services are delivered by telephone.Genet Med advance online publication 18 September 2014Genetics in Medicine (2014); doi:10.1038/gim.2014.125.
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