Ahead of Print -Molecular Evolution of Peste des Petits Ruminants Virus - Volume 20, Number 12—December 2014 - Emerging Infectious Disease journal - CDC
Volume 20, Number 12—December 2014
Molecular Evolution of Peste des Petits Ruminants Virus
Peste des petits ruminants is a highly contagious and devastating viral disease of small ruminants that is endemic to much of Africa, the Middle East, and Asia (1,2). The causative agent, PPRV virus (PPRV), belongs to the familyParamyxoviridae, genus Morbillivirus (3) and groups with rinderpest virus (RPV), measles virus (MV), and canine distemper virus. Sheep and goats are the major hosts of PPRV, and infection has also been reported in a few wild small ruminant species (2). Researchers have speculated that RPV eradication has further enabled the spread of PPRV (4,5). Transmission of PPRV from infected goats to cattle has been recently reported (6), and PPRV antigen has been detected in lions (7) and camels (8). These reports suggest that PPRV can switch hosts and spread more readily in the absence of RPV (4,6,8). This host range switch had previously been seen after eradication of smallpox virus, which created a niche for monkeypox and cowpox viruses to cross the species barrier into humans (4).
PPRV has caused numerous serious epidemics in small ruminant populations across sub-Saharan Africa, the Middle East, and major parts of the Indian subcontinent where PPRV is considered endemic (1). In recent years, PPRV has extended its range southward in Africa as far as southern Tanzania (2008) and the Democratic Republic of Congo and Angola (2012). PPR outbreaks have also been reported across North Africa, including within Tunisia (2006), Morocco (2008), and Algeria (2011). In addition, within Europe, Turkey reported ≈20 laboratory-confirmed PPR outbreaks in sheep and goats during 2011–2012. In southwestern Asia, the virus spread to Tibet (2007) and has recently been reported throughout China (2013–2014). It is unclear what factors have favored emergence and spread of the disease, but millions of small ruminants across these regions must now be considered at high risk for infection with PPRV (9). The huge effect on small ruminant production has resulted in PPRV emerging as a global animal health concern.
The molecular epidemiology of PPRV, which is based on sequence comparison of a small region of the fusion (F) gene (322 nt) or the nucleoprotein (N) gene (255 nt), has identified 4 distinct lineages (I–IV) of PPRV (2). However, this analysis has not generated much information on the evolution and dispersal of PPRV lineages. Lineage I PPRV had gone undetected for 19 years being detected in Senegal in 1994. Lineage IV PPRV, which was believed initially to be confined to India and the Middle East, now has a wider geographic presence and appears to be evolving rapidly. Many aspects of PPRV evolution, such as ancestral virus location, divergence and time of origin, and historical and geographic patterns of spread, are poorly understood (10). A better understanding of the evolution of PPRV would enable prediction of how these viruses will lead to further outbreaks and epidemics and provide data for control strategies.
Advanced sequencing technologies have enabled molecular epidemiologic studies of viruses in which whole gene and complete genome data are used to enhance and clarify the evolutionary dynamics of viral infectious disease (11). We analyzed genome data for all 4 lineages of PPRV. This analysis will enable a more precise evolutionary and phylogenetic assessment of the relationships between lineages by reducing the associated estimation errors and increased higher confidence in estimates.
Mr Muniraju is a final year doctoral student at The Pirbright Institute, Pirbright, UK. His primary research interests are epidemiologic studies of PPRV and developing marker vaccines for peste des petits ruminants by using reverse genetics techniques.
We thank Vincent Michaud for his critical reading of and comments on the manuscript.
This study was supported by grants EU-BBSRC Anihwa BB/L013657/1, BBSRC-DFID CIDLID BB/H009485/1, and DBT-BBSRC FADH BB/L004801/1.
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Suggested citation for this article: Muniraju M, Munir M, Parthiban AR, Banyard AC, Bao J, Wang Z, et al. Molecular evolution of peste des petits ruminants virus. Emerg Infect Dis [Internet]. 2014 Dec [date cited]. http://dx.doi.org/10.3201/eid2012.140684
1Preliminary results were presented at the 15th International Negative Strand Virus Meeting; Granada, Spain, June 16–21, 2013 (http://www.nsvmeeting2013.com/sites/default/files/nsvmeeting2013_program.pdf).