CIENCIASMEDICASNEWS: NCTR Publications > NCTR Research Highlights

viernes, 8 de agosto de 2014

NCTR Publications > NCTR Research Highlights

NCTR Publications > NCTR Research Highlights

National Center for Toxicological Researh log with FDA on left side

Current Highlight from July 25, 2014

Combination Testing Strategy for DILI Prediction

Scientists from NCTR, Kaohsiung Medical University, Fudan University and Hannover Medical School have developed a new testing strategy for compounds that incorporates high-content screening (HCS) assays with the “rule-of-two” predictive model (RO2) to improve predictions of drug-induced liver injury (DILI). In this study, the RO2 model, defined by high daily doses and compound lipophilicity, was used to prioritize compounds for testing in a primary rat hepatocyte-based HCS assay. This improved accuracies by 10% and reduced the number of drugs requiring experimental assessment by 20% as compared to utilization of the HCS assay alone. This new testing strategy may improve the prediction of DILI using in vitro assays in early drug development. This study was published in Archives of Toxicology