lunes, 4 de agosto de 2014

Impact of Family History on Prostate Cancer Mortality... [J Urol. 2014] - PubMed - NCBI

Impact of Family History on Prostate Cancer Mortality... [J Urol. 2014] - PubMed - NCBI

 2014 Jul 24. pii: S0022-5347(14)04034-8. doi: 10.1016/j.juro.2014.07.085. [Epub ahead of print]

Impact of Family History on Prostate Cancer Mortality in Caucasian Men Undergoing PSA-Based Screening.



To assess if prostate cancer (PCa) screening reduces PCa mortality in Caucasian men with a family history (FH) of prostate cancer.


Data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial was used to compare screening and usual care arms within the subset of men with and without a FH of PCa. Univariate, multivariate cox regression analysis, and log-rank analysis of Kaplan-Meier curves were used to examine the data for differences in PCa specific survival.


A total of 65,179 Caucasian subjects were included in the PSA screening trial, of which 7314 (11.2%) were diagnosed with PCa. Only 4,833 (7.4%) of Caucasian men had a FH of PCa. FH+ men had a significantly higher PCa incidence (16.9% vs. 10.8%; p<0.01) and higher PCa specific mortality (0.56% vs. 0.37%; P<0.01), which trended to significance in multivariate analysis (HR 1.47, 95% CI: 0.98-2.21; p=0.06). Screening FH+ men also showed a trend towards decreased PCa specific mortality with a hazard ratio of 0.49 (95% CI 0.22-1.1; p=0.08) and also a reduced time to death from PCa (log-rank; p=0.05).


Caucasian men with a FH of PCa are at increased risk of being diagnosed and subsequently dying from prostate cancer. Yearly digital rectal exams and PSA testing may reduce prostate cancer death in these individuals.
Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.


Family History; PSA; Prostate Cancer; Screening

[PubMed - as supplied by publisher]

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