Genomics & Cancer Precision Medicine: Are we there yet?
Transforming NCI’s Clinical Trials ProgramsNCI has transformed its clinical research programs to keep pace with advances in the scientific understanding of cancer. With the creation of the National Clinical Trials Network and NCI Community Oncology Research Program, systemic changes are in place that will improve cancer research and lead to improvements in care for the 1.6 million Americans diagnosed with cancer every year.
- National Clinical Trials Network (NCTN)
NCTN is a new clinical trials research network that provides an infrastructure for NCI treatment, screening, and diagnosis trials. The new infrastructure allows investigators to begin clinical trials more quickly, reach conclusions faster, and offer patients studies that incorporate precision medicine at over 3,000 clinical trials sites.
- NCI Community Oncology Research Program (NCORP)
NCORP is a community-based program that builds upon the scope and activities of NCI's previously supported community networks: the NCI Community Clinical Oncology Program (CCOP) and NCI Community Cancer Centers Program (NCCCP). The program brings cancer clinical trials, as well as cancer care delivery research (CCDR), to individuals in their own communities, thereby generating a broadly applicable evidence base that contributes to improved patient outcomes and a reduction in cancer disparities.
Learn more about the changing landscape of NCI clinical trials below.
Implementation of the NCI’s National Clinical Trials Network (March 20, 2014)
An NCI Perspective Article that explains the goals that will guide the new clinical trials system and how the changes will enhance NCI-supported clinical trials.
Statement on Forthcoming Changes in NCI’s Clinical Trials Programs (April 4, 2014)
An overview explaining the need for clinical trials reform and specific components of the system.
Open Letter to the Cancer Community Regarding Community Clinical Trials (April 10, 2014)
Harold Varmus reaffirms NCI’s commitment to patients in community clinical trials and explains the transition from the CCOPs and the NCCCP to a new network, NCORP.
Teleconference Summary: NCI Clinical Trials Systems (May 16, 2014)
A summary of the opening remarks given by NCI leadership during a teleconference for the advocacy community highlighting changes to the NCI clinical trials enterprise.
Other NCI Programs That Sponsor or Conduct Clinical TrialsNCI supports clinical research in many ways, beyond just the NCTN and NCORP. Numerous other programs directly or indirectly support clinical research.
Cancer Therapy Evaluation Program (CTEP)
CTEP is the program within the Division of Cancer Treatment and Diagnosis that plans, assesses, and coordinates all aspects of clinical trials.
Center for Cancer Research
The Center for Cancer Research at NIH in Bethesda, Maryland exists to seek answers for critical questions about a particular diseases or disease process and to identify promising new therapeutic interventions that can then be confirmed in larger studies carried out across the country at cancer centers participating in NCI-supported research.
CCR Clinical Trials at NIH
Cancer clinical trials conducted at NIH are aimed at answering critical questions about a particular disease or disease process and at identifying promising new therapeutic interventions that can then be confirmed in larger studies carried out across the country at cancer centers participating NCI-supported research.
Office of Cancer Centers
OCC supports major academic and research institutions throughout the United States to sustain broad-based, coordinated, interdisciplinary programs in cancer research.
NCI-Designated Cancer Centers
NCI-Designated Cancer Centers develop and translate scientific knowledge from promising laboratory discoveries into new treatments for cancer patients. They are at the forefront of NCI-supported efforts at universities and cancer research centers across the United States. Find a center near you and learn about their research capabilities and patient services.
NCI's Cancer Imaging Program - Clinical Trials
Promotes and supports cancer-related basic, translational, and clinical research in imaging sciences and technology, and integration and application of these imaging discoveries and developments to the understanding of cancer biology and to the clinical management of cancer and cancer risk.
Clinical Trials Coordination and Development
- Coordinating Center for Clinical Trials
Facilitates efforts across NCI to enhance the effectiveness of the NCI's clinical trials enterprise through collaboration and harmonization among NCI programs and extramural stakeholder communities.
- The NCI Experimental Therapeutics (NExT) Program
The NExT program is designed to safely shorten the timeline for new drug development.
Programs That Provide Support to Clinical Trials
- Developmental Therapeutics Program
As the drug discovery and development arm of NCI, the Developmental Therapeutics Program plans, conducts, and facilitates the development of therapeutic agents for cancer and AIDS.
- NCI/CTEP Collaborations
Links to CTEP initiatives and collaborative programs that facilitate conducting and developing clinical trials.
Selected NCI-Sponsored Clinical Trials
- Featured Clinical Trials Supported by the National Cancer Institute
Summaries of selected NCI-sponsored cancer trials.
- Noteworthy Clinical Trials
Information about major NCI-supported clinical trials, open or closed to patient enrollment.