Inflammatory Bowel Disease: Genomics & Public Health
CDC information: What is Inflammatory Bowel Disease (IBD)? The greatest relative risk of IBD disease is found among first-degree relatives, suggesting a strong genetic component.
Patient page: Inflammatory bowel disease- Crohn disease and ulcerative colitis are the 2 major types of IBD![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Jill Jin JAMA May 21, 2014
Jill Jin JAMA May 21, 2014
Crohn disease: 82 genomewide association studies have reported on genetic factors in Crohn disease,
check out the HuGE Navigator
Ulcerative colitis: 28 genomewide association studies have reported on genetic factors, check out the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
The most commonly reported genes are NOD2/CARD15 and IL23R
The most commonly reported genes are NOD2/CARD15 and IL23R
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Luke Jostins et al. Nature (2012)
Luke Jostins et al. Nature (2012)
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