domingo, 6 de abril de 2014

Does risk of endometrial cancer for women with... [Gynecol Oncol. 2014] - PubMed - NCBI

Does risk of endometrial cancer for women with... [Gynecol Oncol. 2014] - PubMed - NCBI



 2014 Mar 11. pii: S0090-8258(14)00243-1. doi: 10.1016/j.ygyno.2014.03.011. [Epub ahead of print]

Does risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair gene depend on family history of endometrial cancer or colorectal cancer?

Abstract

OBJECTIVE:

To determine whether risk of endometrial cancer for women without a germline mutation in a DNA mismatch repair (MMR) gene depends on family history of endometrial or colorectal cancer.

METHODS:

We retrospectively followed a cohort of 79,166 women who were recruited to the Colon Cancer Family Registry, after exclusion of women who were relatives of a carrier of a MMR gene mutation. The Kaplan-Meier failure method was used to estimate the cumulative risk of endometrial cancer. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for association between family history of endometrial or colorectal cancer and risk of endometrial cancer.

RESULTS:

A total of 628 endometrial cancer cases were observed, with mean age at diagnosis of 54.4 (standard deviation: 15.7) years. The cumulative risk of endometrial cancer to age 70years was estimated to be 0.94% (95% CI 0.83-1.05) for women with no family history of endometrial cancer, and 3.80% (95% CI 2.75-4.98) for women with at least one first- or second-degree relative with endometrial cancer. Compared with women without family history, we found an increased risk of endometrial cancer for women with at least one first- or second-degree relative with endometrial cancer (HR 3.66, 95% CI 2.63-5.08), and for women with one first-degree relative with colorectal cancer diagnosed at age <50years (HR 1.48, 95% CI 1.15-1.91).

CONCLUSION:

An increased risk of endometrial cancer is associated with a family history of endometrial cancer or early-onset colorectal cancer for women without a MMR gene mutation, indicating for potential underlying genetic and environmental factors shared by colorectal and endometrial cancers other than caused by MMR gene mutations.
Copyright © 2014 Elsevier Inc. All rights reserved.

KEYWORDS:

Colorectal cancer, Endometrial cancer, Family history, Lynch syndrome, Mismatch repair

PMID:
 
24631449
 
[PubMed - as supplied by publisher]

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