Detection of Novel Rotavirus Strain by Vaccine Postlicensure Surveillance - Vol. 19 No. 8 - August 2013 - Emerging Infectious Disease journal - CDC
Table of Contents
Volume 19, Number 8–August 2013
Volume 19, Number 8—August 2013
Detection of Novel Rotavirus Strain by Vaccine Postlicensure Surveillance
Active vaccine postlicensure surveillance for rotavirus-associated diarrhea is informative for determination of vaccine effectiveness and for characterization of disease-associated rotavirus genotypes (1–5). Most rotaviruses circulating in the United States belong to a limited number of strains, routinely characterized by serologic or genetic identification of the outer capsid protein antigens viral protein (VP) 7, which defines G types, and VP4, which defines P types (6,7). Of circulating strains in the United States, 85% contain a G or P antigen that is included in both US-licensed rotavirus vaccines (2,8). However, > 70 G and P antigen combinations have been reported, and uncommon strains may suddenly appear in a new geographic area (1,2,5,9). Ongoing active surveillance is conducted through the Centers for Disease Control and Prevention’s New Vaccine Surveillance Network, a prospective, population-based surveillance program for acute gastroenteritis among children < 5 years old, the details of which have been published (3–5). This surveillance has detected the emergence of G12P and G9P rotavirus genotypes, as well as 3 reported instances of US children infected with G8P rotavirus (3–5,10). During the 2009 winter season (December 2008–June 2009) in Rochester, New York, 54 (30%) of 183 enrolled children with acute gastroenteritis had rotavirus infection. Fifty (94%) of 51 rotavirus strains were typical US strains, with G or P antigens contained in the licensed rotavirus vaccines; 3 were G8P (10). One strain, however, appeared to be an unusual reassortant not previously reported in human infection. We describe this novel rotavirus genotype, G14P, found along with enteric adenovirus in a stool sample from a child with diarrhea.