Novel G10P[14] Rotavirus Strain, Northern Territory, Australia - Vol. 19 No. 8 - August 2013 - Emerging Infectious Disease journal - CDC
Table of Contents
Volume 19, Number 8–August 2013
Volume 19, Number 8—August 2013
Dispatch
Novel G10P[14] Rotavirus Strain, Northern Territory, Australia
Abstract
We identified a genotype G10P[14] rotavirus strain in 5 children and 1 adult with acute gastroenteritis from the Northern Territory, Australia. Full genome sequence analysis identified an artiodactyl-like (bovine, ovine, and camelid) G10-P[14]-I2-R2-C2-M2-A11-N2-T6-E2-H3 genome constellation. This finding suggests artiodactyl-to-human transmission and strengthens the need to continue rotavirus strain surveillance.Two live oral vaccines are available globally: Rotarix (GlaxoSmithKline Biologicals, Melbourne, Victoria, Australia) and RotaTeq (Merck, Whitehouse Station, NJ, USA). Rotarix is a monovalent vaccine that contains a single human G1P[8] strain (3). RotaTeq is a pentavalent vaccine comprised of 5 human–bovine reassortant virus strains (3). Both vaccines were introduced into the Australian National Childhood Immunization Program in July 2007. The strategy of a rotavirus vaccination program is to target the most frequently circulating rotavirus strain(s) and provide homotypic and heterotypic protection.
G10P[14] rotavirus strains are rarely reported as the source of infection in humans. Of 7 previously reported G10P[4] rotavirus infections, 1 each was in the United Kingdom and Thailand and 5 were in Slovenia (4). During 2011, the Australian Rotavirus Surveillance Program identified 6 G10P[14] strains in the Northern Territory (NT). We report the characterization of G10P[14] strains detected in Australia.
No hay comentarios:
Publicar un comentario