Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer

Boris Pasche, MD, PhD

JAMA. 2013;309(24):2598-2599. doi:10.1001/jama.2013.6600.

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Although morbidity and mortality from colorectal cancer have steadily decreased over the past 3 decades, colorectal cancer remains the third most common form of cancer and the third most common cause of cancer death in the United States.¹ Early disease detection through increases in screening that can identify and allow removal of precancerous polyps is thought to be the major reason for the decrease in colorectal cancer incidence.² Additionally, new chemotherapy regimens and targeted therapies have improved the outcome of patients with locally advanced³ and metastatic⁴ colorectal cancer.