Prev Med. 2013 Jul 8. pii: S0091-7435(13)00220-X. doi: 10.1016/j.ypmed.2013.06.028. [Epub ahead of print]
Identifying adolescents with high fasting glucose: The importance of adding grandparents' data when assessing Family History of Diabetes.
Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Alameda Professor Hernâni Monteiro, 4200 - 319 Porto Portugal. Electronic address: firstname.lastname@example.org.
to evaluate the role of adding grandparents' data to parental information to the assessment of a family history of diabetes, in order to identify adolescents with high fasting glucose.
in 2003 we evaluated 1276 population-based 13-year-olds, from Porto, Portugal. The history of diabetes in parents and grandparents was collected using self-reported questionnaires and a clinical evaluation was performed, including a fasting blood sample. The 75th percentile of fasting plasma glucose (FPG = 91 mg/dl) was used to create two groups of participants (high vs. low fasting glucose).
no association was found between family history of diabetes (with or without grandparental data) and a high FPG. The sensitivity to identify individuals with high FPG increased from 7.8% to 47.9% when grandparental history was combined with parental data. The positive predictive value was slightly increased (25.2% vs. 27.8%) but the specificity dropped (91.8% vs. 56.4%).
combining parental with grandparental history increased the number of adolescents with a positive family history of diabetes and also increased the sensitivity to identify adolescents with high FPG. So, even if it determines a decrease in specificity, grandparental data is relevant when screening for high fasting glucose in adolescents.
Abnormal Glycemia, Adolescent, Family History, Type 2 Diabetes Mellitus
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