lunes, 15 de julio de 2013

Genomics|Update|Current ► Painkillers Overdose: Genetic Differences in Drug Metabolism


Features of the Week

Painkillers Overdose: Genetic Differences in Drug Metabolism

lots of pills and pill containers
CDC Vital Signs:  Prescription painkiller overdoses- a growing epidemic, especially among women
Skyrocketing epidemic among women: Prescription painkiller overdoses,External Web Site Icon by Tom Frieden, CDC Director, Huffington Post, Jul 6
Find out how opioid prescription drugs are affected by genetic differences in metabolism and which drugs have labels or dosing guidelinesExternal Web Site IconPharmGKB:External Web Site Icon A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchers
PharmGKB: The Pharmacogenomics Knowledge BaseExternal Web Site Icon
Thorn CF, et al. Methods Mol Biol 2013;1015:311-20
Should codeine & tramadol be avoided in ultrarapid metabolizers? And do the 10% of the population who are poor metabolizers not get any benefit at all?External Web Site Icon
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of Cytochrome P450 2D6 (CYP2D6) genotype.External Web Site Icon
Relling M et al Clin Pharma Thera (2012) 91(2): 321–326.

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