Features of the Week
Painkillers Overdose: Genetic Differences in Drug Metabolism
CDC Vital Signs: Prescription painkiller overdoses- a growing epidemic, especially among women
Skyrocketing epidemic among women: Prescription painkiller overdoses,
by Tom Frieden, CDC Director, Huffington Post, Jul 6 Find out how opioid prescription drugs are affected by genetic differences in metabolism and which drugs have labels or dosing guidelines
PharmGKB: A comprehensive resource that curates knowledge about the impact of genetic variation on drug response for clinicians and researchersPharmGKB: The Pharmacogenomics Knowledge Base
Thorn CF, et al. Methods Mol Biol 2013;1015:311-20
Should codeine & tramadol be avoided in ultrarapid metabolizers? And do the 10% of the population who are poor metabolizers not get any benefit at all?
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of Cytochrome P450 2D6 (CYP2D6) genotype.
Relling M et al Clin Pharma Thera (2012) 91(2): 321–326.
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