lunes, 1 de abril de 2013

Preconception folic acid supplementation an... [Am J Med Genet A. 2013] - PubMed - NCBI

Preconception folic acid supplementation an... [Am J Med Genet A. 2013] - PubMed - NCBI

2013 Mar;161(3):438-44. doi: 10.1002/ajmg.a.35796. Epub 2013 Feb 7.

Preconception folic acid supplementation and risk for chromosome 21 nondisjunction: A report from the National Down Syndrome Project.


Department of Human Genetics, Emory University, Atlanta, Georgia.


Both a lack of maternal folic acid supplementation and the presence of genetic variants that reduce enzyme activity in folate pathway genes have been linked to meiotic nondisjunction of chromosome 21; however, the findings in this area of research have been inconsistent. To better understand these inconsistencies, we asked whether maternal use of a folic acid-containing supplement before conception reduces risk for chromosome 21 nondisjunction. Using questionnaire data from the National Down Syndrome Project, a population-based case-control study, we compared the use of folic acid-containing supplements among mothers of infants with full trisomy 21 due to maternal nondisjunction (n = 702) and mothers of infants born with no major birth defects (n = 983). Using logistic regression, adjusting for maternal age, race/ethnicity, and infant age at maternal interview, we found no evidence of an association between lack of folic acid supplementation and maternal nondisjunction among all case mothers (OR = 1.16; 95% CI: 0.90-1.48). In analyses stratified by meiotic stage and maternal age (<35 1.08-3.71="" 2.00="" 2013="" 95="" account="" acid="" age="" aging="" among="" an="" and="" as="" associated="" association="" be="" by="" ci:="" confirmed="" could="" data="" each="" errors.="" errors="" experiencing="" folic="" for="" found="" if="" ii="" in="" inc.="" inconsistencies="" lack="" maternal="" may="" meiosis="" meiotic="" mii="" mothers="" nondisjunction="" of="" older="" oocyte.="" or="" p="" periodicals="" previous="" proportion="" results="" sample="" specifically="" structure="" studies="" study="" suggest="" supplementation="" that="" the="" these="" vary="" we="" wiley="" with="" years="">Copyright © 2013 Wiley Periodicals, Inc.


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