Nature Genetics - iCOGS

Nature Genetics - iCOGS

Foreword

iCOGS collection provides a collaborative model

Nature Genetics is pleased to present the iCOGS Focus comprising a collection of 13 papers from COGS, representing a significant advance in our understanding of genetic susceptibility to three hormone-related cancers: breast, ovarian and prostate cancer. We hope that you will find this Focus issue, as well as the accompanying Focus online, a useful guide to this milestone in genetic epidemiology.

Research Highlights

Breast and ovarian cancer in BRCA1 mutation carriersBreast cancer in BRCA2 mutation carriersBreast cancer associations in east Asian womenFine mapping of the 11q13 breast cancer susceptibility locusFine mapping of prostate cancer associations at TERT locus

Commentary

Public health implications from COGS and potential for risk stratification and screening

Commentary

Turning of COGS moves forward findings for hormonally mediated cancers

Commentary

Research articles

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Douglas Easton, Per Hall et al.

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Rosalind Eeles et al.

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Paul Pharoah, Joellen Schildkraut, Thomas Sellers et al.

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Montserrat Garcia-Closas et al.

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning et al.

Primers

These Primers, or hypertext essays, provide a guided tour through the entire collection of 13 coordinated COGS publications. This new publishing format interlaces editorial analysis with threads, which include a series of direct quotations from relevant sections of the original research publications or editorially written highlights.

Common variation and heritability estimates for breast, ovarian and prostate cancers

Shared susceptibility loci for breast, prostate and ovarian cancers

Functional annotation of susceptibility loci identified by COGS

COGS project and design of the iCOGS array

Risk prediction and population screening for breast, ovarian and prostate cancers