Obesity Susceptibility Loci on Body Mass Index and Weight Loss in Spanish Adolescents after a Lifestyle Intervention.

Moleres A, Rendo-Urteaga T, Zulet MA, Marcos A, Campoy C, Garagorri JM, Martínez JA, Azcona-Sanjulián MC, Marti A; EVASYON Study Group.

Source

Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.

Abstract

OBJECTIVE:

To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents.

STUDY DESIGN:

Overweight/obese adolescents (n = 168; 12-16 years) participating in the EVASYON program were genotyped for 9 obesity-related single nucleotide polymorphisms in the FTO, MC4R, TMEM18, IL6, PPARG, and ADIPQ genes.

RESULTS:

At baseline, the GPS showed a significant association with body mass index-standard deviation score (BMI-SDS) and fat mass. After 3 months of intervention, this GPS also showed a relationship with the variation of both anthropometric measurements. After adjusting for baseline BMI-SDS, subjects with a lower GPS had a greater improvement on metabolic profile, as well as a better response to physical activity, compared with those subjects with a higher GPS.

CONCLUSIONS:

The GPS seems to have an important relationship with BMI-SDS and fat mass both at baseline and after a 3-month weight loss lifestyle intervention. Obese and overweight adolescents with a lower GPS have a greater benefit of weight loss after 3 months of a multidisciplinary lifestyle intervention.
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