Predictors of contralateral breast cancer in BRCA1... [Br J Cancer. 2011] - PubMed result

Br J Cancer. 2011 Apr 12. [Epub ahead of print]

Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers.
Metcalfe K, Gershman S, Lynch HT, Ghadirian P, Tung N, Kim-Sing C, Olopade OI, Domchek S, McLennan J, Eisen A, Foulkes WD, Rosen B, Sun P, Narod SA.

1] Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada [2] Women's College Research Institute, 790 Bay Street, Room 750, Toronto, Ontario, Canada M5G 1N8.

Abstract
Purpose:The objective of this study was to estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers; and measure the extent to which host, family history, and cancer treatment-related factors modify the risk.Patients and methods:Patients were 810 women, with stage I or II breast cancer, for whom a BRCA1 or BRCA2 mutation had been identified in the family. Patients were followed from the initial diagnosis of cancer until contralateral mastectomy, contralateral breast cancer, death, or last follow-up.Results:Overall, 149 subjects (18.4%) developed a contralateral breast cancer. The 15-year actuarial risk of contralateral breast cancer was 36.1% for women with a BRCA1 mutation and was 28.5% for women with a BRCA2 mutation. Women younger than 50 years of age at the time of breast cancer diagnosis were significantly more likely to develop a contralateral breast cancer at 15 years, compared with those older than 50 years (37.6 vs 16.8%; P=0.003). Women aged <50 years with two or more first-degree relatives with early-onset breast cancer were at high risk of contralateral breast cancer, compared with women with fewer, or no first-degree relatives with breast cancer (50 vs 36%; P=0.005). The risk of contralateral breast cancer was reduced with oophorectomy (RR 0.47; 95% CI 0.30-0.76; P=0.002).Conclusion:The risk of contralateral breast cancer risk in BRCA mutation carriers declines with the age of diagnosis and increases with the number of first-degree relatives affected with breast cancer. Oophorectomy reduces the risk of contralateral breast cancer in young women with a BRCA mutation.British Journal of Cancer advance online publication, 12 April 2011; doi:10.1038/bjc.2011.120 www.bjcancer.com. PMID: 21487411 [PubMed - as supplied by publisher] Predictors of contralateral breast cancer in BRCA1... [Br J Cancer. 2011] - PubMed result