PLoS Medicine: Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement

Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement
Cecile Janssens and colleagues present the GRIPS Statement, a checklist to help strengthen the reporting of genetic risk prediction studies.


A. Cecile J. W. Janssens1*, John P. A. Ioannidis2,3,4,5,6, Cornelia M. van Duijn1, Julian Little7, Muin J. Khoury8, for the GRIPS Group¶

1 Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, 2 Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece, 3 Biomedical Research Institute, Foundation for Research and Technology, Ioannina, Greece, 4 Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America, 5 Center for Genetic Epidemiology and Modeling and Tufts CTSI, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, United States of America, 6 Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, United States of America, 7 Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada, 8 Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

* E-mail: a.janssens@erasmusmc.nl


Summary Points
The rapid and continuing progress in gene discovery for complex diseases is fueling interest in the potential application of genetic risk models for clinical and public health practice.

The number of studies assessing the predictive ability is steadily increasing, but the quality and completeness of reporting varies.

A multidisciplinary workshop sponsored by the Human Genome Epidemiology Network developed a checklist of 25 items recommended for strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS), building on the principles established by prior reporting guidelines.

These recommendations aim to enhance the transparency of study reporting, and thereby to improve the synthesis and application of information from multiple studies that might differ in design, conduct, or analysis.

A detailed Explanation and Elaboration document is published as supporting information (Text S1).

full-text:
PLoS Medicine: Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement