Interest in Genetic Testing for Modest Changes in ... [Public Health Genomics. 2011] - PubMed result

Public Health Genomics. 2011 Apr 2. [Epub ahead of print]

Interest in Genetic Testing for Modest Changes in Breast Cancer Risk: Implications for SNP Testing.
Graves KD, Peshkin BN, Luta G, Tuong W, Schwartz MD.

Department of Oncology and The Jess and Mildred Fisher Center for Familial Cancer Research, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.


Abstract
Background: Advances in genomics may eventually lead to 'personalized genetic medicine,' yet the clinical utility of predictive testing for modest changes in risk is unclear. We explored interest in genetic testing for genes related to modest changes in breast cancer risk in women at moderate to high risk for breast cancer. Methods: Women (n = 105) with a negative breast biopsy and ≥1 relative with breast or ovarian cancer completed telephone surveys. We measured demographic and psychosocial variables and, following presentation of hypothetical scenarios of genetic tests for lower-penetrance breast cancer gene mutations, assessed interest in willingness to pay for and comprehension of test results. We used logistic regression models with generalized estimating equations to evaluate combinations of risk level, cost and behavioral modifiers. Results: Many women (77%) reported 'definite' interest in genetic testing, with greater interest in tests that conveyed more risk and cost less. Behavioral modifiers of risk (taking a vitamin; diet/exercise), having a regular physician, greater perceived benefits of genetic testing, and greater cancer worry also influenced interest. Most participants (63%) did not understand relative vs. absolute risk. Women with less understanding reported more cancer worry and greater willingness to pay for testing. Conclusion: Interest in genetic testing for mutations related to modest changes in risk was high, modified by both test and psychosocial factors. Findings highlight the need for education about benefits and risks of testing for mutations that convey modest changes in risk, particularly given the current lack of clinical validity/utility and availability of direct-to-consumer genetic testing.

Copyright © 2011 S. Karger AG, Basel.
PMID: 21464556 [PubMed - as supplied by publisher]

Interest in Genetic Testing for Modest Changes in ... [Public Health Genomics. 2011] - PubMed result