Genomics|Update|Current: Genomics in the Scientific Literature - Cardiovascular Disease

Genomics in the Scientific Literature
Topics in the Scientific Literature

Cardiovascular Disease
1. Cardiovascular genomics: outcomes and implications
Herrington DM
Can J Cardiol 2010 Mar;26 Suppl A:60A-3A

Can J Cardiol. 2010 Mar;26 Suppl A:60A-63A.

Cardiovascular genomics: outcomes and implications.
Herrington DM.

Wake Forest University School of Medicine, Internal Medicine/Section on Cardiology, Winston Salem, North Carolina 27157, USA. dherring@wfubmc.edu

Abstract
The application of genomics technology to clinical cardiovascular research is producing fundamentally new insights concerning the etiology of cardiovascular disease phenotypes. Recent genome-wide association studies demonstrate clear associations between single nucleotide polymorphisms and important cardiovascular phenotypes. However, risk alleles for the single nucleotide polymorphisms in question do not explain a sufficient portion of individual risk to be useful for screening purposes. Therefore, clinicians should continue to make use of family history to augment risk stratification and emphasize established forms of prevention for their patients with, or at risk for, cardiovascular disease.

PMID: 20386764 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/20386764?dopt=Abstract


2. Genetic causes of high and low serum HDL-cholesterol
Weissglas-Volkov D & Pajukanta P
J Lipid Res 2010 Apr

J Lipid Res. 2010 Apr 26. [Epub ahead of print]

Genetic causes of high and low serum HDL-cholesterol.
Weissglas-Volkov D, Pajukanta P.

University of California, Los Angeles, United States.

Abstract
Plasma levels of high-density lipoprotein cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to extensive search for genetic factors influencing HDL-C concentrations. Over the past 30 years, candidate gene, genome-wide linkage, and most recently genome-wide association (GWA) studies have identified several genetic variations for plasma HDL-C levels. However, the functional role of several of these variants remains unknown and they do not always correlate with CAD. In this review, we will first summarize what is known about HDL metabolism, monogenic disorders associated with both low and high HDL-C levels and candidate gene studies. Then we will focus this review on recent genetic findings from the GWA studies and future strategies to elucidate the remaining substantial proportion of HDL-C heritability. Comprehensive investigation of the genetic factors conferring to low and high HDL-C levels using integrative approaches is important to unravel novel pathways and their relations to CAD, so that more effective means of diagnosis, treatment and prevention will be identified.

PMID: 20421590 [PubMed - as supplied by publisher]Free Article
http://www.ncbi.nlm.nih.gov/pubmed/20421590?dopt=Abstract