Personalized Medicine — Method Developed To Identify Gene Sets Controlling Phenotypes - NCTR Research Highlights

NCTR Research Highlights
Current Highlight from January 8, 2010

Personalized Medicine — Method Developed To Identify Gene Sets Controlling Phenotypes
National Center for Toxicological Research mathematical statisticians have developed a new multivariate analysis of variance (MANOVA) method to identify gene sets that are characteristic of healthy-cell and disease-cell phenotypes. Because phenotype expression is the result of complex interactions between multiple gene and environmental factors, gene sets were analyzed. Individual genes or environmental factors contributing to a phenotype are often not recognized. You also must deal with the commonly encountered statistical problem of these large data sets where the numbers of related genes are often higher than the number of samples that can be analyzed on a practical basis. The new set of algorithms in this MANOVA addresses these issues and will aid in determining risk factors for toxicology and disease. (Bioinformatics 25: 897-903, 2009)

For further information, contact Dr. James Chen, Division of Personalized Nutrition and Medicine, NCTR.

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NCTR Research Highlights