Obesity is associated with a higher risk of clear-cell renal cell carcinoma than with other histologies. William T. Lowrance. 2009; BJU International - Wiley InterScience

Obesity is associated with a higher risk of clear-cell renal cell carcinoma than with other histologies. William T. Lowrance. 2009; BJU International - Wiley InterScience: "Obesity is associated with a higher risk of clear-cell renal cell carcinoma than with other histologies
William T. Lowrance, R. Houston Thompson, David S. Yee, Matthew Kaag, S. Machele Donat and Paul Russo
Department of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Correspondence to Will Lowrance, Department of Surgery, Division of Urology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA.
e-mail: lowrancw@mskcc.org
Copyright © 2010 BJU International
KEYWORDS
kidney neoplasms • carcinoma • renal cell • obesity • body mass index • histology
Study Type – Prognosis (cohort)
Level of Evidence 2a
ABSTRACT
To investigate the association between body mass index (BMI) and histology of renal cell carcinoma (RCC) in a contemporary cohort, as obesity is increasingly prevalent in the USA and might be contributing to the increasing incidence of RCC, but little is known about the relationship of obesity with the different histological subtypes of RCC.
PATIENTS AND METHODS
From January 2000 to December 2007 we identified 1640 patients with renal cortical tumours undergoing surgical extirpation at our institution, and who had their BMI recorded. Multivariable logistic regression models were used to test the association of BMI with RCC histology.
RESULTS
The median (interquartile range) BMI was 28 (25–32) kg/m2 and 38% of patients were classified as obese (BMI >30 kg/m2). After adjusting for tumour size, age, gender, American Society of Anesthesiologists sc"