HIV/AIDS
HIV/AIDS: Public Health and Genomic Insights - March 30, 2014
CDC Info
- CDC information on HIV/AIDS
- CDC information on World AIDS Day
- CDC Vital Signs:HIV care saves lives. Viral suppression is key,November 2014
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Liao HK et al. Nat Commun 2015 6413
Liao HK et al. Nat Commun 2015 6413
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Zhu W et al. Retrovirology 2015 (1) 22
Zhu W et al. Retrovirology 2015 (1) 22
An integrated map of HIV genome-wide variation from a population perspective.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Li G et al. Retrovirology 2015 (1) 18
Li G et al. Retrovirology 2015 (1) 18
Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: A genome-wide association study.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Johnson EO et al. PLoS ONE 2015 (3) e0118149
Johnson EO et al. PLoS ONE 2015 (3) e0118149
HIV latency and the noncoding RNA therapeutic landscape.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Saayman S et al. Adv. Exp. Med. Biol. 2015 169-89
Editing CCR5: A novel approach to HIV gene therapy.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Cornu TI et al. Adv. Exp. Med. Biol. 2015 117-30
Gene therapy strategies to block HIV-1 replication by RNA interference.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Herrera-Carrillo E et al. Adv. Exp. Med. Biol. 2015 71-95
Possible biomarkers for the early detection of HIV-associated heart diseases: A proteomics and bioinformatics prediction.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Rasheed S et al. Comput Struct Biotechnol J 2015 145-52
Targeting the HIV RNA genome: High-hanging fruit only needs a longer ladder.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Le Grice SF J et al. Curr. Top. Microbiol. Immunol. 2015 Mar 4.
Genome editing strategies: potential tools for eradicating HIV-1/AIDS.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Khalili K et al. J. Neurovirol. 2015 Feb 26.
Khalili K et al. J. Neurovirol. 2015 Feb 26.
The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
Herrera-Carrillo E et al. Gene Ther. 2015 Feb 26.
The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Perkins MR et al. J. Infect. Dis. 2015 Feb 20.
Data-intensive analysis of HIV mutations.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
Ozahata M et al. BMC Bioinformatics 2015 Feb 5. (1) 35
HIV-1 adaptation to HLA: a window into virus-host immune interactions.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Carlson JM et al. Trends Microbiol. 2015 Jan 19.
Genomics of HIV infection.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Telenti A et al. Curr Opin HIV AIDS 2015 Mar (2) 77-8
Application of gene-editing technologies to HIV-1.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Drake MJ et al. Curr Opin HIV AIDS 2015 Mar (2) 123-7
Genome editing-based HIV therapies.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
Gu WG et al. Trends Biotechnol. 2015 Mar (3) 172-179
HIV/AIDS: Recent Genomic Insights - December 4, 2014
CDC Vital Signs: HIV care saves lives. Viral suppression is key, November 2014
Recent Advances
Review: influence of ART on HIV genetics.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
Simonetti FR, et al. Curr Opin HIV AIDS. 2014 Nov 11.
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy,
PHG Foundation, Mar 10
Testing for risk and protective trends in genetic analyses of HIV acquisition.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Mccarthy JM, et al. Biostatistics. 2014 Sep 29
Biomarkers of HIV-associated Cancer.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
Flepisi BT, et al. Biomark Cancer. 2014 Jul 3;6:11-20. doi
HIV/AIDS Genomics: Advances in Therapy and Tests - July 31, 2014
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Hu W, et al. PNAS, Jul 21, 2014.
Hu W, et al. PNAS, Jul 21, 2014.
Genome editing cuts out HIV![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Grens K. The Scientist, Jul 21, 2014.
Grens K. The Scientist, Jul 21, 2014.
Gene researchers work to engineer HIV-resistant cells
Hampton T. JAMA, Jul 9, 2014.
Hampton T. JAMA, Jul 9, 2014.
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Tebas P, et al. N Engl J Med. 2014 Mar 6;370(10):901-10.
Promising results from HIV gene editing therapy,
PHG Foundation, Mar 10
Check out guidelines on genomic tests associated with HIV/AIDS treatment, from the CDC evidence-based table
HLA-B*5701/abacavir | |
CCR5-tropic HIV-1 /maraviroc |
Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Cargnin S, et al. Pharmacogenomics. 2014;15(7):963-76.
Did you know? 1799 genes have been reported in relation to HIV risk & outcomes including 33 genomewide association studies. To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uxm8XUxewrlfCQanMmH-Jf6JLqEHNA0tQGa4F_zXWhRTAZb2WaOs0bfVwTAlrIdtq6v4OUICpb2eCYc6cAjauS3y2P02SvO1iuC0x7oUA2VfSkDI3ZFImJ=s0-d)
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