lunes, 16 de enero de 2012

Online Tool to Guide Decisions for BRCA1/2 Muta... [J Clin Oncol. 2012] - PubMed - NCBI

J Clin Oncol. 2012 Jan 9. [Epub ahead of print]

Online Tool to Guide Decisions for BRCA1/2 Mutation Carriers.

Source

Allison W. Kurian, Diego F. Munoz, Elizabeth A. Schackmann, Meredith A. Mills, and Sylvia K. Plevritis, Stanford University School of Medicine, Stanford, CA; Peter Rust, Michael Smith, and Lauren Clarke, Cornerstone Systems Northwest, Lynden, WA.

Abstract

PURPOSEWomen with BRCA1 or BRCA2 (BRCA1/2) mutations must choose between prophylactic surgeries and screening to manage their high risks of breast and ovarian cancer, comparing options in terms of cancer incidence, survival, and quality of life. A clinical decision tool could guide these complex choices. METHODSWe built a Monte Carlo model for BRCA1/2 mutation carriers, simulating breast screening with annual mammography plus magnetic resonance imaging (MRI) from ages 25 to 69 years and prophylactic mastectomy (PM) and/or prophylactic oophorectomy (PO) at various ages. Modeled outcomes were cancer incidence, tumor features that shape treatment recommendations, overall survival, and cause-specific mortality. We adapted the model into an online tool to support shared decision making. RESULTS: //brcatool.stanford.edu" locator-type="url">http://brcatool.stanford.edu ).

PMID:
22231042
[PubMed - as supplied by publisher]
Online Tool to Guide Decisions for BRCA1/2 Muta... [J Clin Oncol. 2012] - PubMed - NCBI

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