domingo, 11 de diciembre de 2011

A cost-effectiveness model of genetic testing for the ... [Heart. 2011] - PubMed - NCBI

Heart. 2011 Nov 29. [Epub ahead of print]

A cost-effectiveness model of genetic testing for the evaluation of families with hypertrophic cardiomyopathy.

Source

Centenary Institute, Sydney, Australia.

Abstract

BackgroundTraditional management of families with hypertrophic cardiomyopathy (HCM) involves periodic lifetime clinical screening of family members, an approach that does not identify all gene carriers owing to incomplete penetrance and significant clinical heterogeneity. Limitations in availability and cost have meant genetic testing is not part of routine clinical management for many HCM families.ObjectiveTo determine the cost-effectiveness of the addition of genetic testing to HCM family management, compared with clinical screening alone.MethodsA probabilistic Markov decision model was used to determine cost per quality-adjusted life-year and cost for each life-year gained when genetic testing is included in the management of Australian families with HCM, compared with the conventional approach of periodic clinical screening alone.ResultsThe incremental cost-effectiveness ratio (ICER) was $A785 (£510 or €587) per quality-adjusted life-year gained, and $A12 720 (£8261 or €9509) per additional life-year gained making genetic testing a very cost-effective strategy. Sensitivity analyses showed that the cost of proband genetic testing was an important variable. As the cost of proband genetic testing decreased, the ICER decreased and was cost saving when the cost fell below $A248 (£161 or €185). In addition, the mutation identification rate was also important in reducing the overall ICER, although even at the upper limits, the ICER still fell well within accepted willingness to pay bounds.ConclusionsThe addition of genetic testing to the management of HCM families is cost-effective in comparison with the conventional approach of regular clinical screening. This has important implications for the evaluation of families with HCM, and suggests that all should have access to specialised cardiac genetic clinics that can offer genetic testing.

PMID:
22128210
[PubMed - as supplied by publisher]
A cost-effectiveness model of genetic testing for the ... [Heart. 2011] - PubMed - NCBI

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