Comparing age of cystic fibrosis diagnosis and treatment initiation after newborn screening with two common strategies.

Sanders DB, Lai HJ, Rock MJ, Farrell PM.

Source

Department of Pediatrics, University of Wisconsin, Madison, WI, United States.

Abstract

BACKGROUND:

Newborn screening (NBS) for CF has become widespread, although there are multiple strategies. Little is known about outcomes such as age of diagnosis after different NBS methods.

METHODS:

We used the U.S. Cystic Fibrosis Foundation Patient Registry to identify infants with CF born between 2001 and 2008 in states that utilized NBS. We compared ages at diagnosis, genotyping, sweat test, and first visit to a CF Centre between states that used serial immunoreactive trypsinogen (IRT/IRT) levels and states that used IRT and DNA analysis (IRT/DNA).

RESULTS:

We identified 1288 infants with CF. Compared to infants born in IRT/IRT states, infants born in IRT/DNA states were younger at the time of diagnosis (median 2.3weeks versus 4.0weeks in IRT/IRT states, p<0.001), genotyping (0.7weeks versus 5.3weeks, p<0.001), and initial CF Centre visit (5.9weeks versus 7.7weeks, p=0.008).

CONCLUSIONS:

Although there is room to improve outcomes with both strategies, infants born in IRT/DNA states have treatment initiated at a younger age than infants born in IRT/IRT states.
Copyright © 2011. Published by Elsevier B.V.