martes, 25 de junio de 2024
Unseen details of human brain structure revealed
https://www.nih.gov/news-events/nih-research-matters/study-reveals-unseen-details-human-brain-structure
At a Glance
Researchers generated a high-resolution map of all the cells and connections in a single cubic millimeter of the human brain.
The results reveal previously unseen details of brain structure and provide a resource for further studies.
Quick test could help reduce dementia care disparities - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/quick-test-could-help-reduce-dementia-care-disparities
At a Glance
A five-minute, culturally neutral test for cognitive problems improved dementia detection and management in older adults.
The simple tool could help increase access to dementia care for people living throughout the U.S, including in disadvantaged areas.
AI tool predicts response to cancer therapy - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/ai-tool-predicts-response-cancer-therapy
At a Glance
Scientists developed an AI tool that uses routine clinical data to identify cancer patients most likely to respond to immunotherapy drugs called checkpoint inhibitors.
The approach could help guide personalized cancer treatments for patients.
Xylitol may affect cardiovascular health - National Institutes of Health,
https://www.nih.gov/news-events/nih-research-matters/xylitol-may-affect-cardiovascular-health
At a Glance
Higher blood levels of the artificial sweetener xylitol were associated with increased risk of heart attack and stroke in people.
Xylitol enhanced blood clotting in mice and isolated human blood.
The results highlight the need for further study of long-term cardiovascular health risks from sugar alcohols, artificial sweeteners that were thought to be safe.
An alternative to brain surgery for patients with epilepsy | Drug Discovery News
An alternative to brain surgery for patients with epilepsy | Drug Discovery News: A gene therapy targeting excitatory neurons significantly reduced seizures in a mouse model of the most common cause of child epilepsy.
A sex-specific protein panel detects early-stage cancers | Drug Discovery News
A sex-specific protein panel detects early-stage cancers | Drug Discovery News: A limited set of plasma proteins identified 18 solid tumors in all major human organs.
Robotic pills deliver gastrointestinal injections | Drug Discovery News
Robotic pills deliver gastrointestinal injections | Drug Discovery News: Researchers developed ingestible capsules that inject drugs into the stomach and small intestine, providing a novel oral delivery method for biologics.
Meet the microrobots primed to take down cancer | Drug Discovery News
Meet the microrobots primed to take down cancer | Drug Discovery News: Sperm, bacteria, bubbles, and shuttles are just some of the latest cancer-treating microrobots in development for human use in the next few years.
The robots making cell therapies | Drug Discovery News
The robots making cell therapies | Drug Discovery News: Scientists and engineers teamed up to use robots to streamline cell therapy manufacturing, aiming to give more patients access to these lifesaving therapies.
The Lancet Series on Gestational Diabetes
https://www.thelancet.com/infographics-do/gestational-diabetes?dgcid=hubspot_email_conferencealerts_lancetgestdiab24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz--xJPvGfbjY4I30StH7fd4rULJHbOawTs4JFwKmwwhlWvnDeFHV4_kv5upuvte6iL7zayleWkim7xMhoCYlbx-K9tZqkw&_hsmi=312875476&utm_content=312875476&utm_source=hs_email
Gestational Diabetes Mellitus (GDM) is the most common medical pregnancy complication worldwide. Early diagnosis and treatment of GDM is greatly needed to improve the health of both woman and child.
The Lancet Series on gestational diabetes Published: June 20, 2024
https://www.thelancet.com/series/gestational-diabetes?dgcid=hubspot_email_conferencealerts_lancetgestdiab24&utm_campaign=conferencealerts&utm_medium=email&_hsenc=p2ANqtz-_3nGsFCgQ1G0UmRJNSMy3U3i6iBOsKYgNSu09UoJo2thsM5zl4RgL5k_j_ZsQ227Y_sr0Bra4VEX7r_i1oGPW9HGe4wg&_hsmi=312875476&utm_content=312875476&utm_source=hs_email
Gestational diabetes is the most common medical pregnancy complication worldwide, affecting one in seven pregnancies. GDM cases are increasing globally alongside a parallel rise in obesity and diabetes in women of childbearing age. Without treatment, gestational diabetes can lead to high blood pressure, increased risk of Caesarean sections, mental health conditions, and complications for the baby at delivery, alongside health complications later in life for both mother and child, such as type 2 diabetes and cardiovascular disease. A new Series on gestational diabetes published in The Lancet calls for a greater focus on early gestational diabetes and a shift to a holistic life-course approach in how we manage the disease. The Series offers a comprehensive and inclusive analysis of the most current evidence on pathophysiology, screening, management, prevention, and long-term complications for mothers and their babies.
lunes, 24 de junio de 2024
Mimicking insect traits kills fungus | Drug Discovery News
Mimicking insect traits kills fungus | Drug Discovery News: Insect wings contain micropillars that kill harmful microbes. Researchers designed a similar titanium surface to prevent fungal infections on medical devices.
An evolving answer to excess sweating | Drug Discovery News
An evolving answer to excess sweating | Drug Discovery News: The cause of hyperhidrosis, an excessive sweating condition, is enigmatic, but treatment options are plentiful and growing.
A missing Y chromosome gene links to heart failure | Drug Discovery News
A missing Y chromosome gene links to heart failure | Drug Discovery News: Researchers revealed a connection between age-related Y chromosome gene loss and increased heart scarring in men.
Spiny mice hold the key to regenerative wound healing | Drug Discovery News
Spiny mice hold the key to regenerative wound healing | Drug Discovery News: Researchers developed a novel approach for activating neutrophils and boosting anti-tumor immunity.
Why Lykos Therapeutics’ MDMA data had a bad trip | Drug Discovery News
Why Lykos Therapeutics’ MDMA data had a bad trip | Drug Discovery News: An FDA advisory panel voted against recommending the psychedelic MDMA for PTSD, puncturing excitement around the drug’s potential.
Neutrophil backpacks for cancer immunotherapy | Drug Discovery News
Neutrophil backpacks for cancer immunotherapy | Drug Discovery News: Researchers developed a novel approach for activating neutrophils and boosting anti-tumor immunity.
The bacteria-fighting skills of non-antibiotic drugs | Drug Discovery News
The bacteria-fighting skills of non-antibiotic drugs | Drug Discovery News: Researchers identified existing medications that target novel pathways in E. coli, offering a potential solution to the growing antibiotic resistance threat.
Stem cell therapy for macular degeneration | Drug Discovery News
Stem cell therapy for macular degeneration | Drug Discovery News: Age-related macular degeneration is the most common cause of vision loss in adults over age 50, but there are few treatments available. Researchers are now developing promising stem cell therapies to treat the disease.
CAR T cells attack fungal infections | Drug Discovery News
CAR T cells attack fungal infections | Drug Discovery News: Mycologists programmed immune cells to attack Aspergillus fumigatus, a common infectious species rapidly growing resistant to antifungals.
Kyverna Therapeutics tests CAR T cells for autoimmune disease | Drug Discovery News
Kyverna Therapeutics tests CAR T cells for autoimmune disease | Drug Discovery News: Rheumatologist James Chung leads efforts to expand CAR T cell therapy beyond the oncology field.
H5N1 BIRD FLU H5N1 bird flu update: Stories include the risk of avian flu transmission to humans, what would be needed for wide availability of a H5N1 vaccine, the perils of bird flu virus in raw milk, and scientific concerns about a potential pandemic.
https://www.statnews.com/topic/h5n1-bird-flu/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8HZUcU6pulWDUknFobp_9hPprk6MgfV91GLsJ1xx1lyKE2qm6BVrJd5BE0OiWD2YK4n9F6B729Yy9q1gwmtNstFehxUg&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Bird flu snapshot: three months later
As the H5N1 outbreak in dairy herds approaches the three-month mark, America’s top animal health official is calling on farmers to step up the use of personal protective equipment, limit traffic onto their farms, and increase cleaning and disinfection practices in their barns and milking parlors.
“The more we learn about H5N1, the more we understand that good biosecurity is a critically important path to containing the virus,” U.S. Department of Agriculture Secretary Tom Vilsack wrote in an Agri-Pulse op-ed on Friday. Vilsack’s plea comes at a time when it’s becoming clear that in addition to slow-walking the testing of animals and farmworkers and resisting the use of PPE, the dairy industry is also struggling to effectively separate sick cows and limit their movement. In a recent USDA survey of affected farms, 60% of respondents acknowledged moving animals off the farm after some of their cows started showing bird flu symptoms.
Bird flu snapshot: USDA secretary urges farmers to take protective measures
Megan Molteni
By Megan Molteni June 24, 2024
https://www.statnews.com/2024/06/24/bird-flu-snapshot-usda-secretary/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-87-txzNM6_W-kvIIo5y2AeQz0wyroVCA4QyPF2sIJGGw8824InyswmfJkTB4W_e-19ON8MtKaa7_8Bp7jwqhUjfRr0qg&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
In dribs and drabs, USDA reports suggest containing bird flu outbreak in dairy cows will be challenging
Helen Branswell
By Helen Branswell June 13, 2024
https://www.statnews.com/2024/06/13/h5n1-bird-flu-usda-reports/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-86yblfbBldeV7dpOSgBjxKhk_j3j6fGduQuaEWJ_YEljGjumm4k9vFlKm91RXN6tIQ_3tcv4S_R9cRlxoF48M5jDAwng&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Loneliness, Lack of Social and Emotional Support, and Mental Health Issues — United States, 2022 Katherine V. Bruss, PsyD1; Puja Seth, PhD1; Guixiang Zhao, MD, PhD1
https://www.cdc.gov/mmwr/volumes/73/wr/pdfs/mm7324-H.pdf?ACSTrackingID=USCDC_921-DM130544&ACSTrackingLabel=This%20Week%20in%20MMWR%3A%20Vol.%2073%2C%20June%2020%2C%202024&deliveryName=USCDC_921-DM130544&utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-_K43CgihC8VH_UX7HVI4i0wBIDpjTjiveQD0NGYiDthQIdRJr9RnVP9VIp01dPDA1TxL0awhDQItlvLyL6VjYf3IwaiQ&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Who is the most lonely, according to the CDC
The CDC recently released a report on loneliness, lack of social and emotional support, and mental health issues. Here are some of the takeaways that struck me most:
It may sound intuitive, but the data show that people who reported loneliness and a lack of social or emotional support were significantly more likely to experience mental health problems, including stress, frequent distress, and depression.
One in three U.S. adults feel lonely, but bisexual and trans adults in particular are nearly twice as likely as their straight and cis peers to report loneliness. These groups also reported the most stress, frequent mental distress, and depression.
People are more likely to be lonely if they’re ages 18 to 34, have less than a high school education, never married, or have a household income below $25,000.
Women are lonelier than men, but it’s more common among men to lack social and emotional support. (Riddle me that, folks.)
‘We’re failing right now’ in type 2 diabetes, FDA chief says Elizabeth Cooney By Elizabeth Cooney June 21, 2024
https://www.statnews.com/2024/06/21/robert-califf-diabetes-type-2-chronic-disease/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--Clmx5K8Xc7JxuvVCaZAh9CeU2s89QYAqH5MVEaPCPZWm83zb00hat6v1FZztJ7TQ8VmmYGt0tf_TLAxEslHRizLzAtA&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
ONE NOTABLE QUOTE
'We’re failing right now.'
That’s FDA Commissioner Robert Califf, speaking about a lack of progress on type 2 diabetes on Friday at the American Diabetes Association conference. He believes that providers are underutilizing options like bariatric surgery and the new obesity drugs for treating an “epidemic” of type 2 diabetes. Califf expressed more hope for the research happening in type 1 diabetes. Read more on Califf’s comments from STAT’s Liz Cooney.
Here are the dozens of weight loss drugs in development to catch a booming market
Elaine Chen
Allison DeAngelis
J. Emory Parker
By Elaine Chen , Allison DeAngelis , and J. Emory Parker
https://www.statnews.com/2023/09/12/new-weight-loss-drug-tracker-novo-nordisk-eli-lilly/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8UKrY8vTzLwdqejKjOmNRcEVV8HI26znkm4qq43-jxvqcCZ8SoqEz_CC-hB2MeaMAunJonuUS47PD4mXQHMm4MUhZ5BQ&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
Sept. 12, 2023
What do new weight loss drugs mean for the future of bariatric surgery?
By Simar BajajAug. 28, 2023
https://www.statnews.com/2023/08/28/obesity-bariatric-surgery-new-weight-loss-drugs/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--mMt9BaJ2wdm7yGsY5DDpsXbPbDoBJnptcZkfQOhkAFcbzECEH5vg9Guf0SIcHMOc2NeVtZtrxQuhqWDx43peWSGiuNw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
THE OBESITY REVOLUTION A new generation of obesity drugs is transforming patients’ lives, dividing medical experts, and spurring the biggest business battle in years. Known as GLP-1-based drugs, this medication class could have the medical and societal impact of blockbuste…
https://www.statnews.com/category/the-obesity-revolution/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8GIuqTfDCs8IhICvVtUJjh6GbLp7fYjOkKm8z8qXE_rD7L-3wbJfvcsBIrMwwhS0klvZDeMumN5QczIUUVlyJSlg01yw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
The Aspen Ideas: Health conference took place this weekend, bringing together leaders from around the world. STAT’s Usha Lee McFarling was there and brings us these tidbits:
Of course, no health conference these days is complete without talking about weight loss drugs. Rep. Larry Bucshon (R-Ind.), also a cardiothoracic surgeon, asked if there was data showing long-term health benefits that could curb health care costs and thus convince Congress to push for the expensive drugs to be paid for by CMS, which private insurers would likely follow. “I think these are the most important studies for us to do right now,” said panelist and cardiologist Harlan Krumholz.
New studies suggest GLP-1 health care costs have only begun to climb
Elaine Chen
By Elaine Chen April 24, 2024
https://www.statnews.com/2024/04/24/weight-loss-drugs-to-drive-health-care-spending-reports-show/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz--QjEy7vBm6OuIarTmYDKJpHhzoHVchvcEzb-C-TDOiO8rT3H2jhGPXy0T3ZSnkcjtjVJxcRjrA_B_oqi7g5EvvC8LQVw&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
What’s the evidence for the surgeon general’s proposed social media warning? Annalisa Merelli By Annalisa Merelli June 17, 2024
https://www.statnews.com/2024/06/17/surgeon-general-social-media-warning-praise-pushback/?utm_campaign=morning_rounds&utm_medium=email&_hsenc=p2ANqtz-8kRcdWIlPN_UMRD0hjU-gQX0nhVO-WT-iZCMvpalM1vkHUBwJ7wZ-HN8TQ9lvrvfT-kBJdA16U7kA2Ux6V8ss0NN-pcA&_hsmi=312829735&utm_content=312829735&utm_source=hs_email
The Aspen Ideas: Health conference took place this weekend, bringing together leaders from around the world. STAT’s Usha Lee McFarling was there and brings us these tidbits:
Sen. John Fetterman (D-Pa.), pictured above on stage in shorts, sneakers, and black Carhartt hoodie, spoke about his mental health struggles, saying that he hears from people daily that his story affected them. “I just want to be the voice I would have wanted to hear,” he said. Fetterman believes that the warning label for social media proposed by Surgeon General Vivek Murthy is a great idea. “If you’re not willing to make it safer … Congress has to force you to do that,” he said.
Director’s Innovation Speaker Series: Beyond the Lab: Navigating Ethical Challenges of Emerging Neurotechnology Date and Time June 25, 2024 2:00–3:00 p.m. ET
https://www.nimh.nih.gov/news/events/announcements/directors-innovation-speaker-series-beyond-the-lab-navigating-ethical-challenges-of-emerging-neurotechnology
NIMH Directors Innovations Series Presents: Beyond the Lab: Navigating Ethical Challenges of Emerging Neurotechnology
Date and Time: June 25, 2024, from 2:00–3:00 p.m. ET
Location: Hybrid
Join us on June 25, 2024, from 2:00–3:00 p.m. ET as Anna Wexler, Ph.D., explores ethical challenges and considerations with expanding neurotechnology from controlled laboratory environments to consumer use.
Dr. Wexler will draw on her research surrounding do-it-yourself, direct-to-consumer, and alternative neurotherapies to highlight the importance of addressing unintended uses of neurotechnology. She will also share insights from her current research efforts about how to guide the ethical development of neurotechnology.
domingo, 23 de junio de 2024
Developing new engineering tools to improve vision loss diagnosis and management, and restore sight
https://engineeringvision.northwestern.edu/
The personal impact of vision loss is immense. The Northwestern University Center for Engineering in Vision and Ophthalmology (CEVO) connects engineering innovations with clinical needs by developing, translating, and disseminating new tools to improve the diagnosis and management of vision loss, and to ultimately restore sight.
sábado, 22 de junio de 2024
Global health for rare diseases through primary care (Posted Jun 21, 2024 8AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=rare&query=home
From the article: " Genetic testing shows promise in diagnosing people with rare diseases, as over 72% of rare diseases have a genetic basis. Next-generation sequencing and other technologies have facilitated the time-effective and cost-effective diagnosis of most genetic diseases, but substantial challenges hinder widespread adoption. The lack of genetic workforce capacity is a global concern, even in high-income countries, with many regions and countries lacking sufficient genetic expertise. The low reimbursement by governments and private insurers for genetic services also poses an additional barrier. The combination of these factors prevent primary care providers from referring people with suspected rare disease to specialists, which delays diagnosis and treatment. "
Genetic Testing for Global Developmental Delay in Early Childhood (Posted Jun 06, 2024 2PM)
From the article: "What are the implications of genetic testing for global developmental delay (GDD) in early childhood? Findings: In this cohort study of 434 children with GDD, a diagnostic positivity rate of 61% was identified when using trio whole exome sequencing combined with copy number variation sequencing. A thorough analysis expanded the scope of indications for genetic testing, and the pathogenesis of GDD was further elucidated using a bioinformatics approach. Meaning: These findings suggest that early use of combined genetic testing for GDD may diminish the misdiagnosis rate, elucidate the etiologic diagnosis, and lay the groundwork for identifying novel early diagnostic biomarkers and intervention targets. "
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=rch&query=home
Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution? (Posted Jun 18, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=HLBS&query=home
From the abstract: "Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed to assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) and the recommended screening criteria in the United Kingdom in identifying individuals with FH-causing variants, presenting a scalable screening criteria for general populations. "
Implications of Provider Specialty, Test Type, and Demographic Factors on Genetic Testing Outcomes for Patients with Autism Spectrum Disorder (Posted Jun 18, 2024 4PM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=nd&query=home
From the abstract: "A minority of patients with autism spectrum disorder (ASD) are offered genetic testing by their providers or referred for genetics evaluation despite published guidelines and consensus statements supporting genetics-informed care for this population. This study aimed to investigate the ordering habits of providers of different specialties and to additionally assess the diagnostic utility of genetic testing by test type, patient sex, and race and ethnicity.
Research biobank participants attitudes towards genetic exceptionalism and health record confidentiality. Victoria Dortenzio et al. J Community Genet 2024 3 (Posted Apr 08, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=fhh&query=home
From the abstract: "The goals of this study were to determine biobank participants’ attitudes towards genetic exceptionalism and confidentiality and whether those attitudes are related to their preference for return of genetic results. An online questionnaire was distributed to patients with an EHR and email address who had previously enrolled in the BioMe Biobank program. Most participants responded with similar levels of concern in scenarios involving the use of genetic information and other types of health information, suggesting that participants want similar protections for genetic data as other types of sensitive health information, particularly mental health and family history records. "
Prediction of progression to type 1 diabetes with dynamic biomarkers and risk scores (Posted May 26, 2024 11AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=diabetes&query=home
From the abstract: "Identifying biomarkers of functional ß-cell loss is an important step in the risk stratification of type 1 diabetes. Genetic risk scores (GRS), generated by profiling an array of single nucleotide polymorphisms, are a widely used type 1 diabetes risk-prediction tool. Type 1 diabetes screening studies have relied on a combination of biochemical (autoantibody) and GRS screening methodologies for identifying individuals at high-risk of type 1 diabetes. "
Family communication of cancer genetic test results in an ethnically diverse population: a qualitative exploration of more than 200 patients (Posted Jun 06, 2024 2PM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=cancer&query=home
From the abstract: " Previous research on family communication of cancer genetic test results has primarily focused on non-Hispanic White patients with high-risk pathogenic variants (PV). There are limited data on patient communication of moderate-risk PVs, variants of uncertain significance (VUS), and negative results. This qualitative study examined communication of positive, negative, and VUS hereditary cancer multi-gene panel (MGP) results in an ethnically and socioeconomically diverse population. "
Our Words Have Power—NIAID Embraces Respectful, Inclusive, and Person-First Language
https://www.niaid.nih.gov/news-events/our-words-have-power?utm_campaign=+61086892&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=
Our Words Have Power—NIAID Embraces Respectful, Inclusive, and Person-First Language
By Jeanne Marrazzo, M.D., M.P.H., NIAID Director
The power of word choice is obvious every day in my life as a researcher, clinician, colleague, patient, spouse, and friend. Language can inform, delight and inspire, but it can mislead and wound if words are not chosen carefully. At worst, language can invoke stigma, shame, and even violence, all of which undermine NIAID’s mission as part of a health agency. Our institute is responsible not only for advancing scientific knowledge, but for doing so in a way that honors the dignity, individuality, and autonomy of the people affected by the health issues we address. For this reason, I am very proud to share the updated NIAID HIV Language Guide, a thoroughly vetted resource to inform our written and verbal communications. This guide originated as a resource for the HIV field, but respectful, inclusive, and person-first language is essential in all scientific communication. I am committed to following the guide in my communications, and strongly encourage all NIAID staff, funded research networks, sites, centers, investigators, and partners to do the same.
Berberine and Weight Loss: What You Need To Know
https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know?nav=govd
Berberine is a substance found in a variety of plants, including goldenseal, barberry, Oregon grape, and others. Plants containing berberine have a long history of use in both Ayurvedic and Chinese medicine. In modern times, plants containing berberine have been used for infections, skin diseases, digestive disorders, and other conditions. Berberine is currently being studied for its effects on diabetes and risk factors for heart disease. Recently, it has become popular as a potential weight loss aid.
The Lancet Breast Cancer Commission - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
https://www.thelancet.com/infographics-do/breast-cancer-commission-2024?dgcid=hubspot_email_infocusalerts-obgyn_feature_lancetbreastcancer24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-_CVvvXDvPs7h_2m2ZEzg2rBxXEarCgpvqq1iAu97zSAJZ2ymPr4zTjdMyxb8eNRcJ1GujlS_lbhoRny634P4bgkne47A&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
Urgent breast cancer challenges can—and should—be tackled. The Lancet Breast Cancer Commission report shows glaring inequities, with many groups with breast cancer being systematically left behind and forgotten. This is a global blunder.
Obstetrics & Gynaecology - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
Stay up to date in your field with our Obstetrics & Gynaecology Collection. Explore all related content published across The Lancet Group.
https://www.thelancet.com/collections/obstetrics-gynaecology?dgcid=hubspot_email_infocusalerts-obgyn_feature%20&parent=001603&startPage=&ContentItemType=fla&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-92NQMSyPXpaFbipAWDwoWNha196wah6kzECnHXvk53D__u7i6wLkbP4girXKd04npRzmI6maRvnAXg_dYLL-leKoUkKQ&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
Menopause 2024 - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
Menopause is an inevitable life stage for half the world’s population, but experiences vary hugely. Some women have few or no symptoms over the menopause transition while others have severe symptoms that impair their quality of life and may be persistent. Many women feel unsupported as they transition menopause. To better prepare and support women, the Lancet Series on menopause argues for an approach that goes beyond specific treatments to empower women with high-quality information, tools to support decision making, empathic clinical care, and workplace adjustments as needed. Targeted support is needed for groups who experience early menopause or treatment-induced menopause, and for those at increased risk of mental health problems. The authors recognise how gendered ageism may contribute to negative experiences of menopause and call for reduced stigma and greater recognition of the value and contribution of older women.
https://www.thelancet.com/series/menopause-2024?dgcid=hubspot_email_infocusalerts-obgyn_feature_lancetmenopause24&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz-86TZPWo7pc6pyQ7FmFFRlJQFvNq1LFq0DPDp9S26Nge1ymsN3lh45BtAED6Amo7UpHDzQ2qcoGvegnlfmiCA28TlTpKw&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
FIGO | World Congress of Gynecology and Obstetrics - In focus: Women & health | Obstetrics & Gynaecology edition – June 2024 Alert
The following content was published by The Lancet Group and presented at the most recent World Congress of Gynecology and Obstetrics.
https://www.thelancet.com/events/conferences/world-congress-gynecology-obstetrics?dgcid=hubspot_email_infocusalerts-obgyn_feature&utm_campaign=infocusalerts-obgyn&utm_medium=email&_hsenc=p2ANqtz--goGiSXZX0OUcYQr4hwQVRLoyG_fKxV0WUX6iUUGMHEqcm4aSYr9NN7mVG8MlsV-Sjx-i1DPH5n6LhQogrzv_8bxLusg&_hsmi=312655227&utm_content=312257287&utm_source=hs_email
viernes, 21 de junio de 2024
CHASING HAPPINESS: WORLD HAPPINESS REPORT REVEALED
Chasing Happiness: World Happiness Report Revealed
By Ivanhoe Broadcast News on June 30, 2024
https://www.ivanhoe.com/?p=33527&preview=1&_ppp=541cc42d99
“HEALTHY” KIDS’ FOODS THAT ARE NOT HEALTHY
“Healthy” Kids’ Foods That Are Not Healthy
By Ivanhoe Broadcast News on June 30, 2024
https://www.ivanhoe.com/?p=33524&preview=1&_ppp=fbdcea7315
CHILL OUT! MONEY-SAVING TIPS FOR BEATING THE HEAT THIS SUMMER
Chill Out! Money-Saving Tips to Beat the Heat This Summer
By Ivanhoe Broadcast News on June 29, 2024
https://www.ivanhoe.com/?p=33522&preview=1&_ppp=85396001e9
RE-ENERGIZE YOUR CAREER: TIPS TO BEAT BOREDOM
Career: Re-Energize with Tips to Beat Boredom
By Ivanhoe Broadcast News on June 29, 2024
https://www.ivanhoe.com/?p=33519&preview=1&_ppp=cf8bff4891
RELEARNING THE ART OF SWALLOWING
Relearning the Art of Swallowing
By Ivanhoe Broadcast News on June 28, 2024
https://www.ivanhoe.com/?p=33573&preview=1&_ppp=b2c714f402
TRAINING BRAIN CELLS TO STOP EPILEPTIC SEIZURES
Training Brain Cells to Stop Epilepsy
By Ivanhoe Broadcast News on June 27, 2024
https://www.ivanhoe.com/?p=33564&preview=1&_ppp=72eeae7171
A BRIGHTER OUTLOOK FOR GLAUCOMA PATIENTS
A Brighter Outlook for Glaucoma Patients
By Ivanhoe Broadcast News on June 26, 2024
https://www.ivanhoe.com/?p=33557&preview=1&_ppp=d3079e91a0
GET A KNEE REPLACED TODAY; DRIVE NEXT WEEK
Get a Knee Replacement Today: Drive Next Week
By Ivanhoe Broadcast News on June 25, 2024
https://www.ivanhoe.com/?p=33550&preview=1&_ppp=9b42b232b8
LAST CHANCE: HOW CAR T-CELL THERAPY SAVED JOHN
How CAR T-Cell Therapy Saved John
By Ivanhoe Broadcast News on June 24, 2024
https://www.ivanhoe.com/?p=33542&preview=1&_ppp=17af0795fa
FDA Approves First Gene Therapy for Treatment of Certain Patients with Duchenne Muscular Dystrophy
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy?utm_medium=email&utm_source=govdelivery
LEVIDYS is an adeno-associated virus vector-based gene therapy indicated in individuals at least 4 years of age:
For the treatment of Duchenne muscular dystrophy (DMD) in patients who are ambulatory and have a confirmed mutation in the DMD gene.
For the treatment of DMD in patients who are non-ambulatory and have a confirmed mutation in the DMD gene (1, 12.2) The DMD indication in non-ambulatory patients is approved under accelerated approval based on expression of ELEVIDYS micro-dystrophin (noted hereafter as “micro-dystrophin”). Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s).
https://www.fda.gov/vaccines-blood-biologics/tissue-tissue-products/elevidys?utm_medium=email&utm_source=govdelivery
Antibiotic Compound Kills Hard-to-Treat, Infectious Bacteria While Sparing Healthy Bacteria in the Gut Posted on June 20th, 2024 by Dr. Monica M. Bertagnolli
https://directorsblog.nih.gov/2024/06/20/antibiotic-compound-kills-hard-to-treat-infectious-bacteria-while-sparing-healthy-bacteria-in-the-gut/
Drug-resistant bacteria are responsible for a rise in serious, hospital-acquired infections, including pneumonia and sepsis. Many of these bacteria are classified as “gram-negative,” and are harder to kill than “gram-positive” bacteria. Unfortunately, the limited number of antibiotics that can help combat these dangerous infections can also damage healthy microbes in the gut, leaving people at risk for other, potentially life-threatening infections. Such antibiotic-induced disruption has also been linked in studies to irritable bowel syndrome, colon cancer, and many other health conditions.
Updated lung function evaluation equation predicted to reclassify lung disease status for millions
https://www.nhlbi.nih.gov/news/2024/updated-lung-function-evaluation-equation-predicted-reclassify-lung-disease-status?utm_source=govdelivery&utm_medium=email&utm_campaign=nhlbi-update-june
Lung function tests are used to detect obstructed airways and these scores are then compared to normal lung function ranges to help diagnose and detect the severity of lung conditions, such as chronic obstructive pulmonary disease (COPD). Researchers have been studying how to update reference ranges for normal lung function with race-neutral criteria and evaluated a recent model, the 2022 Global Lung Function Initiative — which is recommended by the American Thoracic Society and the European Respiratory Society.
Acetaminophen shows promise in warding off acute respiratory distress syndrome, organ injury in patients with sepsis May 20, 2024, 10:00 AM EDT
https://www.nhlbi.nih.gov/news/2024/acetaminophen-shows-promise-warding-acute-respiratory-distress-syndrome-organ-injury?utm_source=govdelivery&utm_medium=email&utm_campaign=nhlbi-update-june
Findings from NIH-supported clinical trial suggests the drug has the greatest benefit in the sickest patients
A National Institutes of Health (NIH)-supported clinical trial has found that intravenous acetaminophen reduced sepsis patients' risk of having organ injury or developing acute respiratory distress syndrome, a serious condition that allows fluid to leak into the lungs.
Meet the Director: Rena D’Souza, D.D.S., M.S., Ph.D., National Institute of Dental and Craniofacial Research
https://magazine.medlineplus.gov/article/meet-the-director-rena-dsouza-d.d.s-m.s-ph.d-national-institute-of-dental-and-craniofacial-research?utm_medium=email&utm_source=govdelivery
Rena D’Souza, D.D.S., M.S., Ph.D., wants everyone to better understand the close link between oral health and the rest of the body. Her passion for research led her to become Director of the National Institute of Dental and Craniofacial Research (NIDCR) in 2021. Dr. D’Souza aims to advance NIDCR’s research mission and help close nationwide gaps in oral health care. She talked to NIH MedlinePlus Magazine about
Report to Congress on Activities Related to Autism Spectrum Disorder and Other Developmental Disabilities FY 2019 - FY 2023
https://iacc.hhs.gov/publications/report-to-congress/2023/
The U.S. Department of Health and Human Services (HHS) has released the FY 2019-2023 Report to Congress on Activities Related to Autism Spectrum Disorder and Other Developmental Disabilities Under the Autism Collaboration, Accountability, Research, Education, and Support Act (Autism CARES Act) of 2019. The report is required by the Autism CARES Act of 2019 and was prepared by the HHS National Autism Coordinator and the Office of National Autism Coordination (ONAC) at the National Institutes of Health (NIH) on behalf of the Office of the HHS Secretary, with contributions from multiple federal departments and agencies.
The report describes the autism-related activities of over 25 federal departments, agencies, divisions, and offices between fiscal years 2019 to 2023. This includes descriptions of federal programs on biomedical and services research, education, health, employment, housing, disability benefits, justice, and disability services. The report provides updates on progress made in implementing the provisions of the Autism CARES Act of 2019, including progress made by federal departments and agencies in implementing the recommendations of the IACC Strategic Plan, as well as information on topics requested by Congress, including the prevalence of autism, progress on diagnosis and interventions, and home and community-based services (HCBS). In addition, the report includes updates on the interagency coordination of autism efforts by the Interagency Autism Coordinating Committee (IACC) and the HHS National Autism Coordinator.
Grieving the loss of your favorite TV show? You’re not alone, study suggests: 'Perfectly understandable' Viewers develop a ‘parasocial relationship’ with favorite characters, researchers say By Shiv Sudhakar Fox News Published June 20, 2024 6:58am EDT
Grieving the loss of your favorite TV show? You’re not alone, study suggests: 'Perfectly understandable'
Viewers develop a ‘parasocial relationship’ with favorite characters, researchers say
By Shiv Sudhakar Fox News
Published June 20, 2024 6:58am EDT
https://www.foxnews.com/health/grieving-loss-favorite-tv-show-not-alone-study-suggests-perfectly-understandable
Kids with obesity need ‘behavioral counseling,’ task force recommends: 'Call to action' Doctor calls obesity a ‘gateway disease,’ says interventions are ‘vital’ Melissa Rudy By Melissa Rudy Fox News Published June 20, 2024 3:13pm EDT
Kids with obesity need ‘behavioral counseling,’ task force recommends: 'Call to action'
Doctor calls obesity a ‘gateway disease,’ says interventions are ‘vital’
Melissa Rudy By Melissa Rudy Fox News
Published June 20, 2024 3:13pm EDT
https://www.foxnews.com/health/kids-obesity-need-behavioral-counseling-task-force-recommends-call-action
FDA approves new drug to treat autoimmune liver disease: ‘Giant step forward’ Ipsen’s drug, Iqirvo, may help prevent liver scarring and failure, experts said By Amy McGorry Fox News Published June 21, 2024 7:00am EDT
FDA approves new drug to treat autoimmune liver disease: ‘Giant step forward’
Ipsen’s drug, Iqirvo, may help prevent liver scarring and failure, experts said
By Amy McGorry Fox News
Published June 21, 2024 7:00am EDT
https://www.foxnews.com/health/fda-approves-drug-treat-autoimmune-liver-disease-giant-step-forward
jueves, 20 de junio de 2024
Drug Trials Snapshots: INPEFA (sotagliflozin)
INPEFA is a drug that reduces the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with:
heart failure or
type 2 diabetes mellitus, chronic kidney disease, and other cardiovascular risk factors
https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-inpefa
Cancer survivor and world-champion Irish dancer raises money for hospital that saved her life Megan Stuart of Minneapolis was diagnosed with stage 3 neuroblastoma at just 4 months old By Christine Rousselle Fox News Published June 18, 2024 5:00am EDT
Cancer survivor and world-champion Irish dancer raises money for hospital that saved her life
Megan Stuart of Minneapolis was diagnosed with stage 3 neuroblastoma at just 4 months old
By Christine Rousselle Fox News
Published June 18, 2024 5:00am EDT
https://www.foxnews.com/health/cancer-survivor-world-champion-irish-dancer-raises-money-hospital-saved-life
Fatal bacterial infections surging in Japan with unknown cause, reports says Weakened immunity due to COVID pandemic could be a factor, says Tokyo doctor Melissa Rudy By Melissa Rudy Fox News Published June 18, 2024 6:03pm EDT
Fatal bacterial infections surging in Japan with unknown cause, reports says
Weakened immunity due to COVID pandemic could be a factor, says Tokyo doctor
Melissa Rudy By Melissa Rudy Fox News
Published June 18, 2024 6:03pm EDT
https://www.foxnews.com/health/fatal-bacterial-infections-surging-japan-unknown-cause-reports
Men’s energy and vitality plummets for 6 reasons. Boost it back up this way Health experts shared the keys to feeling your best — from better sleep to more movement Melissa Rudy By Melissa Rudy Fox News Published June 19, 2024 5:00am EDT
Men’s energy and vitality plummets for 6 reasons. Boost it back up this way
Health experts shared the keys to feeling your best — from better sleep to more movement
Melissa Rudy By Melissa Rudy Fox News
Published June 19, 2024 5:00am EDT
https://www.foxnews.com/health/mens-energy-vitality-plummets-6-reasons-boost-back
Service dogs save veterans, plus men's energy boosters and safe swimming tips And more of the top Fox News Health stories and videos from the past week By Fox News Staff Fox News Published June 19, 2024 6:24pm EDT
Service dogs save veterans, plus men's energy boosters and safe swimming tips
And more of the top Fox News Health stories and videos from the past week
By Fox News Staff Fox News
Published June 19, 2024 6:24pm EDT
https://www.foxnews.com/health/service-dogs-save-veterans-mens-energy-boosters-safe-swimming-tips
Veterans with PTSD get 'significant' benefits from service dogs, first NIH-funded study finds Military vets placed with service dogs had 66% lower odds of PTSD diagnosis as one man reveals his story Angelica Stabile By Angelica Stabile Fox News Published June 19, 2024 6:37am EDT
Veterans with PTSD get 'significant' benefits from service dogs, first NIH-funded study finds
Military vets placed with service dogs had 66% lower odds of PTSD diagnosis as one man reveals his story
Angelica Stabile By Angelica Stabile Fox News
Published June 19, 2024 6:37am EDT
https://www.foxnews.com/health/veterans-ptsd-significant-benefits-service-dogs-nih-funded-study
Kids with insufficient sleep could see spike in blood pressure, study finds Sleep is one of many factors affecting this key health metric, doctors say Melissa Rudy By Melissa Rudy Fox News Published June 19, 2024 7:03pm EDT
Kids with insufficient sleep could see spike in blood pressure, study finds
Sleep is one of many factors affecting this key health metric, doctors say
Melissa Rudy By Melissa Rudy Fox News
Published June 19, 2024 7:03pm EDT
https://www.foxnews.com/health/kids-insufficient-sleep-could-see-spike-blood-pressure-study-finds
Can you become drunk without drinking alcohol? Here’s how it could happen As experts explain auto-brewery syndrome, a rare condition, an actual case study shows exactly what can happen By Amy McGorry Fox News Published June 20, 2024 4:30am EDT
Can you become drunk without drinking alcohol? Here’s how it could happen
As experts explain auto-brewery syndrome, a rare condition, an actual case study shows exactly what can happen
By Amy McGorry Fox News
Published June 20, 2024 4:30am EDT
https://www.foxnews.com/health/can-you-become-drunk-without-drinking-alcohol-could-happen
Grieving the loss of your favorite TV show? You’re not alone, study suggests: 'Perfectly understandable' Viewers develop a ‘parasocial relationship’ with favorite characters, researchers say By Shiv Sudhakar Fox News Published June 20, 2024 6:58am EDT
Grieving the loss of your favorite TV show? You’re not alone, study suggests: 'Perfectly understandable'
Viewers develop a ‘parasocial relationship’ with favorite characters, researchers say
By Shiv Sudhakar Fox News
Published June 20, 2024 6:58am EDT
https://www.foxnews.com/health/grieving-loss-favorite-tv-show-not-alone-study-suggests-perfectly-understandable
In Alzheimer’s breakthrough, researchers identify ‘protective gene’ that delays disease in high-risk family Among 27 family members with the gene, Alzheimer’s progression was slowed by 5-year average Melissa Rudy By Melissa Rudy Fox News Published June 20, 2024 5:50am EDT
In Alzheimer’s breakthrough, researchers identify ‘protective gene’ that delays disease in high-risk family
Among 27 family members with the gene, Alzheimer’s progression was slowed by 5-year average
Melissa Rudy By Melissa Rudy Fox News
Published June 20, 2024 5:50am EDT
https://www.foxnews.com/health/alzheimers-breakthrough-researchers-identify-gene-delays-disease-high-risk-family
miércoles, 19 de junio de 2024
Cannabis and Cannabinoids (PDQ®)–Health Professional Version / Medicinal Mushrooms (PDQ®)–Health Professional Version / Mistletoe Extracts (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq?cid=eb_govdel#top
Medicinal Mushrooms (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq?cid=eb_govdel#top
Mistletoe Extracts (PDQ®)–Health Professional Version
https://www.cancer.gov/about-cancer/treatment/cam/hp/mistletoe-pdq?cid=eb_govdel#top
Implications of Provider Specialty, Test Type, and Demographic Factors on Genetic Testing Outcomes for Patients with Autism Spectrum Disorder Original Article Published: 11 June 2024
https://link.springer.com/article/10.1007/s10803-024-06423-1
From the abstract: "A minority of patients with autism spectrum disorder (ASD) are offered genetic testing by their providers or referred for genetics evaluation despite published guidelines and consensus statements supporting genetics-informed care for this population. This study aimed to investigate the ordering habits of providers of different specialties and to additionally assess the diagnostic utility of genetic testing by test type, patient sex, and race and ethnicity. "
Improving the Detection of Potential Cases of Familial Hypercholesterolemia: Could Machine Learning Be Part of the Solution?
https://www.ahajournals.org/doi/10.1161/JAHA.123.034434
From the abstract: "Familial hypercholesterolemia (FH), while highly prevalent, is a significantly underdiagnosed monogenic disorder. Improved detection could reduce the large number of cardiovascular events attributable to poor case finding. We aimed to assess whether machine learning algorithms outperform clinical diagnostic criteria (signs, history, and biomarkers) and the recommended screening criteria in the United Kingdom in identifying individuals with FH-causing variants, presenting a scalable screening criteria for general populations. "
How the ‘mind’s eye’ calls up visual memories from the brain Different patterns of brain activity help to distinguish between images recalled from memory and the sight of physical objects. By Julian Nowogrodzki
https://www.nature.com/articles/d41586-024-01757-3?utm_source=Live+Audience&utm_campaign=1b1214596f-nature-briefing-daily-20240617&utm_medium=email&utm_term=0_b27a691814-1b1214596f-50432164
Picture a strawberry. Most people can easily distinguish between that image in their mind’s eye and an actual strawberry. Now researchers say that they’ve worked out how the brain draws this distinction and where in the brain the process happens.
High Body Mass Index in Children and Adolescents: Interventions June 18, 2024
Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/obesity-in-children-and-adolescents-screening
Pioneering research center aims to revolutionize prenatal and neonatal health © Copyright 2024 Children's National Hospital
Catherine Limperopoulos, Ph.D., was drawn to understanding the developing brain, examining how early adverse environments for a mother can impact the baby at birth and extend throughout its entire lifetime. She has widened her lens – and expanded her team – to create the new Center for Prenatal, Neonatal & Maternal Health Research at Children’s National Hospital.
https://innovationdistrict.childrensnational.org/pioneering-research-center-aims-to-revolutionize-prenatal-and-neonatal-health/
Adjusting key protein could improve brain function in children with fetal alcohol syndrome © Copyright 2024 Children's National Hospital
Reduced levels of a protein – called apolipoprotein E – are responsible for the lifelong cognitive and neurological symptoms in fetal alcohol spectrum disorders (FASD), according to a new study published in the journal Molecular Psychiatry. For the first time, researchers at Children’s National Hospital are testing whether controlling the level of this protein could serve as an effective treatment for the poor neurobehavioral outcomes tied to FASD, which is believed to affect roughly 5% of school-aged children.
https://innovationdistrict.childrensnational.org/adjusting-key-protein-could-improve-brain-function-in-children-with-fetal-alcohol-syndrome/
Next-generation genomics testing holds key to undiagnosed rare disease © Copyright 2024 Children's National Hospital
https://innovationdistrict.childrensnational.org/next-generation-genomics-testing-holds-key-to-undiagnosed-rare-disease/
Seth Berger, M.D., Ph.D., felt the pull to dig deeper when he started reading the chart. An 11-year-old boy had an abnormal gait and couldn’t even walk in a straight line down the sidewalk to go trick-or-treating. Yet workups with neurology, orthopedics and an exome analysis of the patient’s genetic code did not provide a diagnosis. He had been getting worse for roughly three years.
Bird flu is highly lethal to some animals, but not to others. Scientists want to know why BY MIKE STOBBE Updated 5:57 PM GMT-3, June 14, 2024
https://apnews.com/article/bird-flu-humans-animals-deaths-ae01d3717783f0cf41e23f3fedb97017?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50432164
NEW YORK (AP) — In the last two years, bird flu has been blamed for the deaths of millions of wild and domestic birds worldwide. It’s killed legions of seals and sea lions, wiped out mink farms, and dispatched cats, dogs, skunks, foxes and even a polar bear.
‘Gold mine’ of century-old wheat varieties could help breeders restore long lost traits Historic traits could make modern wheat more resilient to disease and other stressors 17 JUN 20243:20 PM ETBYERIK STOKSTAD
https://www.science.org/content/article/gold-mine-century-old-wheat-varieties-could-help-breeders-restore-long-lost-traits?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50432164
An antique collection of wheat from around the world could breathe new vigor into the staple. When plant breeders created modern wheat during the 19th and 20th centuries, they focused on crossing and selectively breeding a few key varieties, creating a finicky racehorse of a crop: high yielding but vulnerable to disease, heat, and drought and reliant on a liberal application of fertilizer. Part of the solution, according to a study published today by Nature, may lie in the genetic diversity in 827 kinds of wheat, many of them long vanished from farms.
How climate change is hitting Europe: three graphics reveal health impacts A growing body of research reveals the deaths and diseases linked to rising temperatures across the continent. By Carissa Wong
https://www.nature.com/articles/d41586-024-02006-3?utm_source=Live+Audience&utm_campaign=507caab053-nature-briefing-daily-20240618&utm_medium=email&utm_term=0_b27a691814-507caab053-50432164
Global warming is costing lives, deepening health inequality and driving the spread of disease-carrying ticks and parasites across Europe, according to a major report.
martes, 18 de junio de 2024
Study discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease All autoimmune and inflammatory diseases — including IBD — appear to be caused by a single gene Melissa Rudy By Melissa Rudy Fox News Published June 16, 2024 7:50pm EDTStudy discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease All autoimmune and inflammatory diseases — including IBD — appear to be caused by a single gene Melissa Rudy By Melissa Rudy Fox News Published June 16, 2024 7:50pm EDT
Study discovers 'trigger gene' in IBD as researchers look for drugs to prevent the bowel disease
All autoimmune and inflammatory diseases — including IBD — appear to be caused by a single gene
Melissa Rudy By Melissa Rudy Fox News
Published June 16, 2024 7:50pm EDT
https://www.foxnews.com/health/study-discovers-trigger-gene-ibd-researchers-look-drugs-prevent-bowel-disease
More people sent to hospital as mushroom-infused 'microdosing' chocolate faces ongoing FDA probe Diamond Shruumz 'microdosing' candy products are being investigated by FDA Andrea Vacchiano By Andrea Vacchiano Fox News Published June 16, 2024 8:01pm EDTMore people sent to hospital as mushroom-infused 'microdosing' chocolate faces ongoing FDA probe Diamond Shruumz 'microdosing' candy products are being investigated by FDA Andrea Vacchiano By Andrea Vacchiano Fox News Published June 16, 2024 8:01pm EDT
More people sent to hospital as mushroom-infused 'microdosing' chocolate faces ongoing FDA probe
Diamond Shruumz 'microdosing' candy products are being investigated by FDA
Andrea Vacchiano By Andrea Vacchiano Fox News
Published June 16, 2024 8:01pm EDT
https://www.foxnews.com/health/more-people-sent-hospital-mushroom-infused-microdosing-chocolate-faces-ongoing-fda-probe
Ask a doctor: ‘Why do I keep eating foods that I know are bad for me?’ Experts reveal what drives poor choices — and how to get back on track By Erica Lamberg Fox News Published June 17, 2024 4:04pm EDT
Ask a doctor: ‘Why do I keep eating foods that I know are bad for me?’
Experts reveal what drives poor choices — and how to get back on track
By Erica Lamberg Fox News
Published June 17, 2024 4:04pm EDT
https://www.foxnews.com/health/ask-doctor-why-keep-eating-foods-know-bad-me
Alzheimer’s blood test achieves faster diagnoses, high accuracy at Mayo Clinic Doctors discuss how the test works, how it measures up against other methods Melissa Rudy By Melissa Rudy Fox News Published June 17, 2024 9:34pm EDT
Alzheimer’s blood test achieves faster diagnoses, high accuracy at Mayo Clinic
Doctors discuss how the test works, how it measures up against other methods
Melissa Rudy By Melissa Rudy Fox News
Published June 17, 2024 9:34pm EDT
https://www.foxnews.com/health/alzheimers-blood-test-achieves-faster-diagnoses-high-accuracy-mayo-clinic
Cancer survivor and world-champion Irish dancer raises money for hospital that saved her life Megan Stuart of Minneapolis was diagnosed with stage 3 neuroblastoma at just 4 months old By Christine Rousselle Fox News Published June 18, 2024 5:00am EDT
Cancer survivor and world-champion Irish dancer raises money for hospital that saved her life
Megan Stuart of Minneapolis was diagnosed with stage 3 neuroblastoma at just 4 months old
By Christine Rousselle Fox News
Published June 18, 2024 5:00am EDT
https://www.foxnews.com/health/cancer-survivor-world-champion-irish-dancer-raises-money-hospital-saved-life
Water safety tips from experts for families and caregivers as drowning deaths increase From choosing the right bathing suit color to installing pool alarms, these 8 tips can help prevent tragic accidents By Amy McGorry Fox News Published June 18, 2024 4:00am EDT
Water safety tips from experts for families and caregivers as drowning deaths increase
From choosing the right bathing suit color to installing pool alarms, these 8 tips can help prevent tragic accidents
By Amy McGorry Fox News
Published June 18, 2024 4:00am EDT
https://www.foxnews.com/health/water-safety-tips-experts-families-caregivers-drowning-deaths-increase
FINFLUENCERS: GOOD ADVICE OR SOCIAL MEDIA MISINFORMATION
Finfluencers: Good Advice Or Social Media Misinformation?
By Ivanhoe Broadcast News on June 23, 2024
https://www.ivanhoe.com/?p=33478&preview=1&_ppp=d1f28f5806
BE SUN-WISE THIS SUMMER! THE GOOD, THE BAD, & THE HEALTH EFFECTS
Be Sun-Wise This Summer! The Good, The Bad & The Health Impacts
By Ivanhoe Broadcast News on June 23, 2024
https://www.ivanhoe.com/?p=33475&preview=1&_ppp=a71ef581b7
CYBER SAFE: PROTECT YOURSELF ONLINE
Cyber Safe: Protect Yourself Online
By Ivanhoe Broadcast News on June 22, 2024
https://www.ivanhoe.com/?p=33472&preview=1&_ppp=ca0a81ef99
FROM CAMPUS TO CAREER: JOB HUNTING 101
Job Hunting 101: From Campus To Career
By Ivanhoe Broadcast News on June 22, 2024
https://www.ivanhoe.com/?p=33469&preview=1&_ppp=600e276fb2
EQUALITY IN HEALTHCARE: GENETIC TESTING FOR EVERYONE?
Genetic Testing for Everyone?: Equality in Healthcare
By Ivanhoe Broadcast News on June 21, 2024
https://www.ivanhoe.com/?p=33516&preview=1&_ppp=4e26e3edf9
BREAKTHROUGH TREATMENT MAKES DAD CANCER-FREE
Breakthrough Treatment Makes Dad Cancer-Free
By Ivanhoe Broadcast News on June 20, 2024
https://www.ivanhoe.com/?p=33508&preview=1&_ppp=9b4ffa74ba
THE LINK BETWEEN CHRONIC PAIN AND DEPRESSION
The Link Between Chronic Pain and Depression
By Ivanhoe Broadcast News on June 19, 2024
https://www.ivanhoe.com/?p=33501&preview=1&_ppp=dbe33479f8
BUILDING A “BARRICAID” FOR BACK PAIN
Building a “Barricaid” for Back Pain
By Ivanhoe Broadcast News on June 18, 2024
https://www.ivanhoe.com/medical-breakthroughs/building-a-barricaid-for-back-pain/
THE NEW “NO REHAB” WRIST REPLACEMENT
The New “No Rehab” Wrist Replacements
By Ivanhoe Broadcast News on June 17, 2024
https://www.ivanhoe.com/medical-breakthroughs/the-new-no-rehab-wrist-replacements/
Patterns, Prognostic Implications, and Rural-Urban Disparities in Optimal GDMT Following HFrEF Diagnosis Among Medicare Beneficiaries
https://pubmed.ncbi.nlm.nih.gov/37943222/
Patterns, prognostic implications, and rural-urban disparities in optimal GDMT following HFrEF diagnosis among Medicare beneficiaries
Patterns and disparities in guideline-directed medical therapy (GDMT) uptake for heart failure with reduced ejection fraction (HFrEF) across rural vs urban regions are not well described. This study aimed to evaluate patterns, prognostic implications, and rural-urban differences in GDMT use among Medicare beneficiaries following new-onset HFrEF.
Author: Amgad Mentias, Neil Keshvani, Andrew Sumarsono, Rohan Desai, Muhammad Shahzeb Khan, Venu Menon, Eileen Hsich, Adam P. Bress, Joshua Jacobs, Ramachandran S. Vasan, Gregg C. Fonarow, and Ambarish Pandey
Journal: JACC Heart Failure, June 2024
Place-based strengths and vulnerabilities for mental wellness among rural minority older adults: an intervention development study protocol
https://pubmed.ncbi.nlm.nih.gov/38844399/
Place-based strengths and vulnerabilities for mental wellness among rural minority older adults: an intervention development study protocol
This community-driven mixed-method study used quantitative surveys, qualitative interviews and ecological network research with 125 rural American Indian and Latinx older adults in New Mexico and 28 professional and non-professional social supporters to elucidate how place-based vulnerabilities and protective factors shape experiences of depression among older adults.
Author: Elise Trott Jaramillo
Journal: BMJ Open, June 6
Risk of dementia due to Co-exposure to air pollution and neighborhood disadvantage
https://pubmed.ncbi.nlm.nih.gov/38493859/
Risk of dementia due to Co-exposure to air pollution and neighborhood disadvantage
Co-exposure to air pollution and neighborhood disadvantage may influence cognition decline. This study tested these associations in the context of dementia risk.
Author: Seth Frndak, Zhengyi Deng, Cavin K. Ward-Caviness, Irena Gorski-Steiner, Roland J. Thorpe, and Aisha S. Dickerson
Journal: Environmental Research, June 15
Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones
https://pubmed.ncbi.nlm.nih.gov/38817359/
Statin use is not associated with inflammation among Chilean women of Mapuche and non-Mapuche ancestry with gallstones
Statins are prescribed to lower cholesterol and can also decrease the risk of gallstone formation by reducing inflammation. Researchers assessed whether statin use reduces inflammation among women who have already developed gallstones. They analyzed 92 inflammation markers among 400 women in Chile, including 200 women with Mapuche Amerindian ancestry and 200 women of Latina/European ancestry.
Author: Sarah S. Jackson, Marina Lex, Vanessa Van De Wyngard, Paz Cook, Allan Hildesheim, Ligia A. Pinto, Sharon H. Jackson, Kelvin Choi*, Tsion Zewdu Minas, Héctor Fabio Losada Morales, Juan Carlos Araya, Catterina Ferreccio, Jill Koshiol, and Ruth M. Pfeiffer
Journal: Future Science OA, May 15
Adult obesity treatment and prevention: A trans-agency commentary on the research landscape, gaps, and future opportunities
https://pubmed.ncbi.nlm.nih.gov/38830619/
Adult obesity treatment and prevention: A trans-agency commentary on the research landscape, gaps, and future opportunities
In response to the worsening obesity epidemic and the many unknowns regarding the disease, a group of key scientific and program staff members of the National Institutes of Health and other federal and non-government agencies gathered virtually in September 2021 to discuss the current state of obesity research, research gaps, and opportunities for future research in adult obesity prevention and treatment. This article synthesizes presentations given by attendees and shares their organizations' current initiatives and identified gaps and opportunities.
Author: Rebecca K. Hoffman, Laurie Friedman Donze, Tanya Agurs-Collins, Brook Belay, David Berrigan, Heidi M. Blanck, Andrea Brandau, Amanda Chue, Susan Czajkowski, Glenn Dillon, Lyudmyla Kompaniyets, Bramaramba Kowtha, Rui Li, Priscah Mujuru*, Lanay Mudd, Linda Nebeling, Naomi Tomoyasu, Deborah Young-Hyman, Xincheng Ted Zheng, and Charlotte Pratt
Journal: Obesity Reviews, June 3
Association Between Discrimination and Depressive Symptoms Among Hispanic or Latino Adults During the COVID-19 Pandemic: Cross-Sectional Study
https://pubmed.ncbi.nlm.nih.gov/38843512/
Association between discrimination and depressive symptoms among Hispanic or Latino adults during the COVID-19 pandemic: cross-sectional study
Discrimination and xenophobia toward Hispanic and Latino communities increased during the COVID-19 pandemic, likely inflicting significant harm on the mental health of Hispanic and Latino individuals. Pandemic-related financial and social instability has disproportionately affected Hispanic and Latino communities, potentially compounding existing disparities and worsening mental health. This study aimed to examine the association between discrimination and depressive symptoms during the COVID-19 pandemic among a national sample of Hispanic and Latino adults.
Author: Cameron K. Ormiston*, Kevin Villalobos*, Francisco Alejandro Montiel Ishino*, and Faustine Williams*
Journal: JMIR Formative Research, June 6
Association of depression and self-reported health status by birthplace and citizenship status: Results from the 2010-2018 National Health Interview Survey
https://pubmed.ncbi.nlm.nih.gov/38851433/
Association of depression and self-reported health status by birthplace and citizenship status: Results from the 2010-2018 National Health Interview Survey
Self-reported health (SRH) is an important indicator of mental health outcomes. More information, however, is needed on whether this association varies by birthplace (defined as US-born or non-US-born) and citizenship status (i.e., non-US-born citizen, non-US citizen, and US-born citizen). Researchers examined the associations between SRH and depression among non-US-born US citizens, non-US citizens, and US-born citizens aged 18 years and older using weighted cross-sectional data from the 2010-2018 National Health Interview Survey.
Author: Cameron K. Ormiston*, Lohuwa Mamudu, Timothy S McNeel, Zhuoqiao Wang, Dennis W. Buckman, and Faustine Williams*
Journal: Journal of Affective Disorders, June 7
Noninvasively Stimulating Deep Brain Areas to Treat Depression Symptoms
https://www.nimh.nih.gov/news/science-news/2024/noninvasively-stimulating-deep-brain-areas-to-treat-depression-symptoms
Changes in brain activity are known contributors to the risk for depression. Can altering the activity between brain areas also offer a treatment for this common but serious mood disorder?
A neuroimaging study funded by the National Institute of Mental Health explored whether a brain stimulation therapy known as repetitive transcranial magnetic stimulation (rTMS) could target regions deep in the brain via their surface connections. The study offers new evidence that stimulating deeper brain areas can reduce depression symptoms and identifies a possible target for improved depression treatment.
Rarity Life Issue 10 Published on Jun 17, 2024
https://issuu.com/raritylife/docs/rarity_life_issue_10/10
Rarity Life is an online publication that offers those affected by rare disease, disability and cancer the opportunity to create content that is truly inclusive, to unify our collective experience and to celebrate and share our differences.
lunes, 17 de junio de 2024
FDA approves pembrolizumab with chemotherapy for primary advanced or recurrent endometrial carcinoma
https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pembrolizumab-chemotherapy-primary-advanced-or-recurrent-endometrial-carcinoma?utm_medium=email&utm_source=govdelivery
On June 17, 2024, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) with carboplatin and paclitaxel, followed by single-agent pembrolizumab, for adult patients with primary advanced or recurrent endometrial carcinoma.
6 Things To Know About Psychological and Physical Approaches for Substance Use Disorders
https://www.nccih.nih.gov/health/tips/things-to-know-about-mind-and-body-approaches-for-substance-use-disorders?nav=govd
Some psychological and physical complementary health approaches (mind and body practices) may be helpful as part of comprehensive treatment for substance abuse and addiction.
Mindfulness-based interventions may help people reduce their use of substances such as alcohol, cigarettes, and opioids.
When used in addition to standard care, music therapy may lead to reductions in cravings and increase motivation for people who are receiving treatment for substance use disorders.
Some research suggests that acupuncture may be helpful in reducing withdrawal/craving and anxiety symptoms. However, there aren’t enough consistent data to support the use of acupuncture for substance use disorder treatment.
EURORDIS launches call for applications to Digital & Data Advisory Group (DAG) +++
EURORDIS – Rare Diseases Europe is expanding its team of volunteers and inviting applications to our Digital and Data Advisory Group (DAG). The group provides advice to EURORDIS on all aspects of digital health policies and procedures, with the mission of recognising and acting upon opportunities for people living with rare diseases.
https://www.eurordis.org/call-for-applications-to-digital-data-advisory-group/
The State of Health in the EU
Conference in the framework of the Belgian presidency of the Council of the European Union
https://www.eesc.europa.eu/en/agenda/our-events/events/state-health-eu
Earlier this month, EURORDIS Board Member Tomasz Grybek spoke at the European Economic and Social Committee’s Conference on the 'State of Health in the EU' in a dedicated panel on rare disease. He spoke of the need for a European Action Plan for Rare Diseases, and highlighted the importance of health remaining a priority amongst EU political and financial choices.
Genetic diagnostic technology a game changer for rare diseases, but ethics concerns linger
By Vasiliki Angouridi | Euractiv's Advocacy Lab
https://www.euractiv.com/section/health-consumers/news/genetic-diagnostic-technology-a-game-changer-for-rare-diseases-but-ethics-concerns-linger/
Euractiv's latest article on genetic diagnostic technology features Jessie Dubief, EURORDIS' Social Research Director. The article highlights the Rare Barometer diagnostic survey findings, and reports on last month's session on diagnosis at our European Conference on Rare Diseases and Orphan Products (ECRD 2024).
European Parliament Elections 2024: What They Mean for Rare Disease Advocacy June 2024
https://www.eurordis.org/european-parliament-elections-2024-what-they-mean-for-rare-disease-advocacy/
After the European Parliament election, it’s time to unpack what it means for the rare disease community across Europe. Our latest article outlines what happens next.
The newly elected MEPs will have a busy schedule ahead of them: from 16-19 July, they will gather in Strasbourg to elect their President and key officials. They will also subsequently be electing the new President of the European Commission, shaping the next five years of EU policymaking.
We want to make sure rare diseases remain high on the political agenda. Ahead of the elections, many European Parliament candidates, across the political spectrum, signed our #ActRare2024 campaign pledge, committing to actions that will improve the lives of the 30 million people in Europe with rare diseases.
The new legislative term presents both challenges and opportunities for our community, and we are ready to collaborate with the new European Parliament and Commission to ensure rare disease policies remain a top priority.
The Lancet Breast Cancer Commission
https://www.thelancet.com/commissions/breast-cancer?dgcid=hubspot_email_infocusalerts-oncology_feature_lancetbreastcancer24&utm_campaign=infocusalerts-oncology&utm_medium=email&_hsenc=p2ANqtz-9lhcrT0NHYqlyOeVZQb4f7KjLHWebh6AJvgq1JvkdfTKN_NnmnmeC0PWQbfBKWNn32Klr5KkcQ_iGXB5u-6fKcDpQlgw&_hsmi=311748437&utm_content=311229495&utm_source=hs_email
Despite tremendous advances in breast cancer research and treatment over the past three decades—leading to a reduction in breast cancer mortality of over 40% in some high-income countries—gross inequities remain, with many groups being systematically left behind, ignored, and even forgotten. The work of the Lancet Breast Cancer Commission highlights crucial groups, such as those living with metastatic breast cancer, and identifies how the hidden costs of breast cancer and associated suffering are considerable, varied, and have far-reaching effects. The Commission offers a forward-looking and optimistic road map for how the health community can course correct to address these urgent challenges in breast cancer.
domingo, 16 de junio de 2024
Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study (Posted Apr 29, 2024 11AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=fhh&query=home
From the article: "Genetic information, if available, could improve T2D prediction among patients lacking measured clinical risk factors. Genome-wide association studies (GWAS) have identified hundreds of unique loci associated with T2D, the results of which can be used to calculate polygenic scores (PGS) that model genetic risk independently of established clinical risk factors including family history. Previous work has evaluated how PGS can be used within healthcare systems, but analyses have been largely cross-sectional in biobanks of mostly European ancestry, limiting the generalizability of results to a more ancestrally and medically diverse US healthcare system. "
Gene–environment interactions in human health (Posted May 29, 2024 9AM)
https://phgkb.cdc.gov/PHGKB/specificPHGKB.action?topic=environmental&query=home
From the abstract: "Gene–environment interactions (G×E), the interplay of genetic variation with environmental factors, have a pivotal impact on human complex traits and diseases. Statistically, G×E can be assessed by determining the deviation from expectation of predictive models based solely on the phenotypic effects of genetics or environmental exposures. Despite the unprecedented, widespread and diverse use of G×E analytical frameworks, heterogeneity in their application and reporting hinders their applicability in public health. "
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