CIENCIASMEDICASNEWS: Linking Synaptic Specificity to Hippocampal Circuit Function

lunes, 27 de abril de 2020

Linking Synaptic Specificity to Hippocampal Circuit Function

	Fluorescence
	The latest fluorescence news from NewsMedical

What is Time-Resolved Fluorescence Spectroscopy?

Linking Synaptic Specificity to Hippocampal Circuit Function

The developmental transition between axon guidance and synapse formation is critical for circuit assembly but still poorly understood. This webinar presents evidence that this key transition can be regulated by axon guidance cues switching their function to regulate synaptogenesis with subcellular specificity.

The presentation discusses Bruker's uncovering of a novel role for the axon guidance molecule Robo2 in excitatory synapse formation in the mouse hippocampus. Cell-autonomous deletion of Robo2 from CA1 pyramidal neurons (PNs) leads to a drastic reduction of the number of excitatory synapses specifically in proximal dendritic compartments.

Join this free Webinar on May 4 to learn more.

Non-Invasive In Vivo Imaging of GFP Expressing Pancreatic Cancer

The in vivo imaging community has been a key benefactor from the discovery of green fluorescent proteins, the characterization and cloning of the protein, along with the extension of the fluorescent protein color pallete. These fluorescent proteins bring light to darkness and make the invisible visible. Fluorescence imaging can even be used for in vivo imaging where the GFP signal must travel through multiple layers of tissue allowing deep tissue imaging of tumors.

Read the Full Article

High-Speed, High-Throughput Cell Counters for Concentration and Viability

The monotonous and often laborious practice of manually counting cells on a hemocytometer has been significantly improved in recent years with the introduction of numerous automated cell-counting instruments. Even with these improvements however, measuring cell concentration and viability for high numbers of samples can still create a bottleneck in many industrial processes and large scale experiments.

	Studying Protein Oligomerization using Fluorescence Microscopy Proteins are important in cellular processes. This article looks at studying proteins using fluorescence microscopy.

	Technology Advances in Bacteria Detection Bacterial infections are an increasing public health threat globally. The ability to rapidly detect infections in life-threatening conditions is vital.

	Novel 3D Imaging Technology Makes Fluorescence Microscopy More Efficient A research team led by Dr Kevin Tsia from the University of Hong Kong (HKU), developed a new optical imaging technology -- Coded Light-sheet Array Microscopy (CLAM) -- which can perform 3D imaging at high speed, and is power efficient and gentle to preserve the living specimens during scanning at a level that is not achieved by existing technologies.

	New technique for imaging proteins in 3D A team of scientists including researchers at the National Synchrotron Light Source II (NSLS-II)--a U.S. Department of Energy Office of Science User Facility at DOE's Brookhaven National Laboratory--have demonstrated a new technique for imaging proteins in 3-D with nanoscale resolution.