People have used marijuana, also called cannabis, for a variety of health conditions for at least 3,000 years. More recently, individual components of marijuana or similar synthetic substances have also been used for health purposes. Some of these substances are called cannabinoids. Despite a lack of robust evidence, cannabinoids—such as cannabidiol (CBD)—are often assumed to be safe and effective in managing pain and used for such purposes in real-world settings. Nine new research awards, funded by our Center at NIH, will investigate the potential pain-relieving properties and mechanisms of action of the diverse phytochemicals in cannabis, including both minor cannabinoids and terpenes. These awards will strengthen the evidence regarding cannabis components and whether they have potential roles in pain management.
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