Monoclonal Antibodies That Neutralize Norovirus
3D graphical representation of a single norovirus virion, set against a white background. Though subtle, the different colors represent different regions of the organism’s outer protein shell, or capsid. Photo Credit: CDC
Vaccines and therapies to prevent and treat norovirus infections do not exist, despite the worldwide prevalence of norovirus infections. The available technology relates to chimpanzee-human chimeric monoclonal antibodies that specifically bind to norovirus and have therapeutic potential. The antibodies that were tested in a primate model of infection have shown protection against norovirus and may have application as immunoprophylaxis to protect individuals from infections or as a possible treatment for infected individuals, or it can be used to develop a diagnostic for detection of norovirus infections. Read more about this exciting collaboration opportunity: https://www.ott.nih.gov/
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