Creutzfeldt-Jakob Disease and Prion Diseases
Creutzfeldt-Jakob disease: Public Health and Genomics - June 11, 2015
CDC and Related Info
- Classic Creutzfeldt-Jakob disease
- Variant Creutzfeldt-Jakob disease
- Genes reported in relation to Creutzfeldt-Jakob disease, including genomewide association studies via theHuGE Navigator
A naturally occurring variant of the human prion protein completely prevents prion disease.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Asante EA et al. Nature 2015 Jun 10.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Asante EA et al. Nature 2015 Jun 10.
Genetic mutation blocks prion disease: Unknown mechanism helped some people in Papua New Guinea escape historic, deadly outbreak,
by B Deng, Nature News and Comments, June 10
The influence of PRNP polymorphisms on human prion disease susceptibility: an update.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Kobayashi A et al. Acta Neuropathol. 2015 May 29.
Kobayashi A et al. Acta Neuropathol. 2015 May 29.
A new practical diagnostic test for Creutzfeldt-Jakob disease.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Brown P et al. Infect Control Hosp Epidemiol 2015 May 7. 1
Brown P et al. Infect Control Hosp Epidemiol 2015 May 7. 1
Rapidly progressive young-onset dementias: neuropsychiatric aspects.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Shrestha R et al. Psychiatr. Clin. North Am. 2015 Jun (2) 221-232
Shrestha R et al. Psychiatr. Clin. North Am. 2015 Jun (2) 221-232
Validation of 14-3-3 protein as a marker in sporadic Creutzfeldt-Jakob disease diagnostic.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Schmitz M et al. Mol. Neurobiol. 2015 May 7.
Schmitz M et al. Mol. Neurobiol. 2015 May 7.
Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt-Jakob disease.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Kipkorir T et al. Proteomics 2015 May 1.
Kipkorir T et al. Proteomics 2015 May 1.
A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Sanchez-Juan P et al. PLoS ONE 2014 (4) e0123654
Sanchez-Juan P et al. PLoS ONE 2014 (4) e0123654
Rare structural genetic variation in human prion diseases.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Lukic A et al. Neurobiol. Aging 2015 May (5) 2004.e1-8
Lukic A et al. Neurobiol. Aging 2015 May (5) 2004.e1-8
Creutzfeldt-Jakob Disease: Recent Insights - August 14, 2014
A test for Creutzfeldt–Jakob disease using nasal brushings![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Christina D. Orrú et al. New England Journal Medicine, August 6, 2014
Christina D. Orrú et al. New England Journal Medicine, August 6, 2014
Novel ways to detect Creutzfeld-Jacob disease?
Daniela Lamas, Blog New England Journal Medicine, Aug 6
CDC information: Classic Creutzfeldt-Jakob disease
CDC information: Variant Creutzfeldt-Jakob disease
National Institute of Neurological Disorders and Stroke: About 5 to 10 percent of cases in the United States are hereditary. In hereditary Creutzfeldt-Jakob Disease , the person has a family health history of the disease and/or tests positive for a genetic mutation associated with disease![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
22 genes have been reported with Creutzfeldt-Jakob Disease, including 3 genomewide association studies/ The most known gene is the prion protein PRNP. To find out more, visit the HuGE Navigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Genetic variation in prion protein PRNP has been associated with several human diseases. To find out more, visit the HuGENavigator![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_sTOQXSz98DkiVr599EHle6XoRFsNJKsms-6eK7JZXK2xMEh4thMlRSTLMSBlaucQCBeW87KGynLIASkyNRbuxjTv3aussFzSE6feLWtJAJ_GJDNzJ-NJ1W=s0-d)
Using science for health: lessons from Creutzfeldt-Jakob disease,
by Dr Philippa Brice, PHG Foundation, Aug 13
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