04/29/2015 12:33 PM EDT
Source: National Library of Medicine -
Related MedlinePlus Page: Liver Diseases
Related MedlinePlus Page: Liver Diseases
Congenital bile acid synthesis defect type 1
What is congenital bile acid synthesis defect type 1?
Congenital bile acid synthesis defect type 1 is a disorder characterized by cholestasis, a condition that impairs the production and release of a digestive fluid called bile from liver cells. Bile is used during digestion to absorb fats and fat-soluble vitamins, such as vitamins A, D, E, and K. People with congenital bile acid synthesis defect type 1 cannot produce (synthesize) bile acids, which are a component of bile that stimulate bile flow and help it absorb fats and fat-soluble vitamins. As a result, an abnormal form of bile is produced.
The signs and symptoms of congenital bile acid synthesis defect type 1 often develop during the first weeks of life, but they can begin anytime from infancy into adulthood. Affected infants often have a failure to gain weight and grow at the expected rate (failure to thrive) and yellowing of the skin and eyes (jaundice) due to impaired bile flow and a buildup of partially formed bile. Excess fat in the feces (steatorrhea) is an additional feature of congenital bile acid synthesis defect type 1. As the condition progresses, affected individuals can develop liver abnormalities including an enlarged liver (hepatomegaly), inflammation, or chronic liver disease (cirrhosis). The spleen may also become enlarged (splenomegaly). The inability to absorb certain fat-soluble vitamins (vitamin D in particular) can result in softening and weakening of the bones (rickets) in some individuals.
If left untreated, congenital bile acid synthesis defect type 1 often leads to cirrhosis and death in childhood.
How common is congenital bile acid synthesis defect type 1?
The prevalence of congenital bile acid synthesis defect type 1 is unknown; however, it is the most common of all the congenital defects of bile acid synthesis. Together, these conditions are thought to have a prevalence of 1 to 9 per million people.
What genes are related to congenital bile acid synthesis defect type 1?
Mutations in the HSD3B7 gene cause congenital bile acid synthesis defect type 1. The HSD3B7 gene provides instructions for making an enzyme called 3 beta-hydroxysteroid dehydrogenase type 7 (3β-HSD7). This enzyme is found in liver cells that produce bile acids. Bile acids are produced from cholesterol in a multi-step process. The 3β-HSD7 enzyme is responsible for the second step in that process, which converts 7alpha(α)-hydroxycholesterol to 7α-hydroxy-4-cholesten-3-one.
HSD3B7 gene mutations result in a 3β-HSD7 enzyme with little or no function. Without enough functional 3β-HSD7 enzyme, the conversion of 7α-hydroxycholesterol to 7α-hydroxy-4-cholesten-3-one is impaired. The 7α-hydroxycholesterol instead gets converted into abnormal bile acid compounds that cannot be transported out of the liver into the intestine, where the bile acids are needed to digest fats. As a result, cholesterol and other fats build up in the liver and fat-soluble vitamins are not absorbed, which contribute to the signs and symptoms of congenital bile acid synthesis defect type 1.
Read more about the HSD3B7 gene.
How do people inherit congenital bile acid synthesis defect type 1?
This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
Where can I find information about diagnosis or management of congenital bile acid synthesis defect type 1?
These resources address the diagnosis or management of congenital bile acid synthesis defect type 1 and may include treatment providers.
- Cleveland Clinic: Cirrhosis of the
- Genetic Testing Registry: Bile acid synthesis defect, congenital,
- MedlinePlus Encyclopedia:
You might also find information on the diagnosis or management of congenital bile acid synthesis defect type 1 in Educational resources and Patient support.
General information about the diagnosis and management of genetic conditions is available in the Handbook. Read more about genetic testing, particularly the difference between clinical tests and research tests.
To locate a healthcare provider, see How can I find a genetics professional in my area? in the Handbook.
Where can I find additional information about congenital bile acid synthesis defect type 1?
You may find the following resources about congenital bile acid synthesis defect type 1 helpful. These materials are written for the general public.
- MedlinePlus - Health information (4 links)
- Additional NIH Resources - National Institutes of Health
- Educational resources - Information pages (6 links)
- Patient support - For patients and families (6 links)
You may also be interested in these resources, which are designed for healthcare professionals and researchers.
- Genetic Testing Registry - Repository of genetic test information (1 link)
ClinicalTrials.gov- Linking patients to medical research PubMed- Recent literature OMIM- Genetic disorder catalog
What other names do people use for congenital bile acid synthesis defect type 1?
- 3beta-HSDH deficiency
- 3beta-hydroxy-delta-5-C27-steroid dehydrogenase deficiency
- 3beta-hydroxy-delta-5-C27-steroid oxidoreductase deficiency
For more information about naming genetic conditions, see the Genetics Home Reference Condition Naming Guidelines and How are genetic conditions and genes named? in the Handbook.
What if I still have specific questions about congenital bile acid synthesis defect type 1?
Where can I find general information about genetic conditions?
The Handbook provides basic information about genetics in clear language.
- What does it mean if a disorder seems to run in my family?
- What are the different ways in which a genetic condition can be inherited?
- If a genetic disorder runs in my family, what are the chances that my children will have the condition?
- Why are some genetic conditions more common in particular ethnic groups?
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding congenital bile acid synthesis defect type 1?
acids ; autosomal ; autosomal recessive ; bile ; cell ; cholesterol ; chronic ; cirrhosis ; congenital ;deficiency ; dehydrogenase ; digestion ; digestive ; enzyme ; failure to thrive ; feces ; gene ;inflammation ; inherited ; intestine ; jaundice ; oxidoreductase ; prevalence ; recessive ; rickets ;soluble ; splenomegaly ; steatorrhea ; synthesis ; vitamins
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (3 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook
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