Am J Clin Pathol. 2014 Aug;142(2):165-72. doi: 10.1309/AJCPHIKRJC67AAZJ.
Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
McCulloch DJ1, Sears MH2, Jacob JT2, Lyon GM2, Burd EM3, Caliendo AM4, Hill CE5, Nix WA6, Oberste MS6, Kraft CS7.
To determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults.
Seventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the VP4 gene and 5' terminus of the VP2 gene. The clinical features and severity of illness associated with the different RV species were compared.
Phylogenetic analysis identified three distinct clusters as RV-A (54%), B (11%), or C (35%) species. In an unadjusted model, patients with RV-B infection were significantly more likely to have the composite outcome variable of death or intensive care unit admission (P = .03), but this effect diminished when controlling for patient sex. A logistic model of the relationship between RV species and adverse outcomes produced nonsignificant odds ratios when controlling for patient sex.
Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders.
Copyright© by the American Society for Clinical Pathology.
Genotype; Rhinovirus; Severity; Species
- [PubMed - in process]