Short Communication
British Journal of Cancer , (4 February 2014) | doi:10.1038/bjc.2014.38
Effect of oral anticoagulants on the outcome of faecal immunochemical test
L Bujanda, C Sarasqueta, Á Lanas, E Quintero, J Cubiella, V Hernandez, J D Morillas, T Perez-Fernández, D Salas, M Andreu, F Carballo, X Bessa, I Portillo, R Jover, F Balaguer, A Cosme, A Castellsand on behalf of COLONPREV study investigators
Abstract
Background:
We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.
Methods:
Individuals aged 50–69 years were invited to receive one FIT sample (cutoff 75 ng ml–1) between November 2008 and June 2011.
Results:
Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3–1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95%CI, 0.4–10.8; P=0.4).
Conclusions:
Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
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