Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations.

Yucesoy B, Talzhanov Y, Johnson VJ, Wilson NW, Biagini RE, Wang W, Frye B, Weissman DN, Germolec DR, Luster MI, Barmada MM.

Source

Toxicology and Molecular Biology Branch, CDC/NIOSH, Morgantown, WV, USA. Electronic address: byucesoy@cdc.gov.

Abstract

The influence of genetic variability within the major histocompatibility complex (MHC) region on variations in immune responses to childhood vaccination was investigated. The study group consisted of 135 healthy infants who had been immunized with hepatitis B (HBV), 7-valent pneumococcal conjugate (PCV7), and diphtheria, tetanus, acellular pertussis (DTaP) vaccines according to standard childhood immunization schedules. Genotype analysis was performed on genomic DNA using Illumina Goldengate MHC panels (Mapping and Exon Centric). At the 1 year post vaccination check-up total, isotypic, and antigen-specific serum antibody levels were measured using multiplex immunoassays. A number of single nucleotide polymorphisms (SNPs) within MHC Class I and II genes were found to be associated with variations in the vaccine specific antibody responses and serum levels of immunoglobulins (IgG, IgM) and IgG isotypes (IgG1, IgG4) (all at p<0 .001="" a="" and="" annotations="" antigen="" can="" childhood="" common="" correlated="" disequilibrium="" efficacy.="" expression="" found="" functional="" genes="" genetic="" group="" hla-a="" hla-c="" hla-dob="" hla-dqa1="" hla-dqb1="" hla-dra="" hla-drb1="" hla-drb5="" hla-g="" hla-h="" immune="" in="" including="" influence="" involved="" linkage="" may="" mhc="" of="" other="" p="" particular="" patterns="" presentation="" processing="" regulate="" regulatory="" response="" results="" showed="" significant="" snps.="" snps="" strongly="" suggest="" tap-2.="" that="" the="" these="" to="" turn="" vaccinations="" vaccine="" variations="" were="" which="" with="" within="">Published by Elsevier Ltd.

KEYWORDS:

CPS, Childhood vaccine, DTaP, Genetic polymorphism, HBV, HBsAg, HLA, Hib, IPV, Ig, Immune response, LD, MHC, Major histocompatibility complex, OR, PCV7, PnPS, SNP, diphtheria, tetanus, and pertussis, haemophilus influenza type b, hepatitis B virus, heptavalent pneumococcal conjugate, human leukocyte antigen, immunoglobulin, inactivated polio vaccine, linkage disequilibrium, major histocompatibility complex, odds ratio, pneumococcal cell wall polysaccharide, pneumococcal polysaccharides, single nucleotide polymorphism, surface antigen of hepatitis B virus