Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function
Article first published online: 25 NOV 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Bilaterally substituted p-terphenyl molecules reproduce the interactions of an α-helix of the HIV-1 protein Rev with its RNA receptor and block Rev function and virus replication. In their Communication (DOI: 10.1002/anie.201306665), J. Alcamí, S. Fustero, and J. Gallego et al. report the structure-based design of terphenyl molecules that inhibit the Rev-mediated transport of HIV-1 RNA from the nucleus to the cytoplasm by binding to the RNA loop that is recognized by Rev (image prepared with the help of M.C. Ibáñez).