Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function - González-Bulnes - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function - González-Bulnes - 2013 - Angewandte Chemie International Edition - Wiley Online Library

Structure-Based Design of an RNA-Binding p-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function

1. Luis González-Bulnes^1,†,
2. Ignacio Ibáñez^2,3,†,
3. Dr. Luis M. Bedoya⁴,
4. Manuela Beltrán⁴,
5. Dr. Silvia Catalán^2,3,
6. Dr. José Alcamí^4,*,
7. Prof. Santos Fustero^2,3,*,
8. Dr. José Gallego^1,*

Article first published online: 25 NOV 2013

DOI: 10.1002/anie.201309856

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Issue

Angewandte Chemie International Edition

Early View (Online Version of Record published before inclusion in an issue)

Additional Information(Show All)

How to CiteAuthor InformationPublication History

SEARCH

Search Scope

Search String

• Advanced >
• Saved Searches >

ARTICLE TOOLS

• Get PDF (349K)
• Save to My Profile
• E-mail Link to this Article
• Export Citation for this Article
• Get Citation Alerts
• Request Permissions

More Sharing ServicesShare|Share on citeulikeShare on connoteaShare on deliciousShare on www.mendeley.comShare on twitter

• Abstract
• Article
• Cited By

View Full Article (HTML) Get PDF (349K)

Bilaterally substituted p-terphenyl molecules reproduce the interactions of an α-helix of the HIV-1 protein Rev with its RNA receptor and block Rev function and virus replication. In their Communication (DOI: 10.1002/anie.201306665), J. Alcamí, S. Fustero, and J. Gallego et al. report the structure-based design of terphenyl molecules that inhibit the Rev-mediated transport of HIV-1 RNA from the nucleus to the cytoplasm by binding to the RNA loop that is recognized by Rev (image prepared with the help of M.C. Ibáñez).