Novel Cyclovirus in Human Cerebrospinal Fluid, Malawi, 2010–2011 - Vol. 19 No. 9 - September 2013 - Emerging Infectious Disease journal - CDC
Table of Contents
Volume 19, Number 9–September 2013
Volume 19, Number 9—September 2013
Novel Cyclovirus in Human Cerebrospinal Fluid, Malawi, 2010–2011
The list of diseases caused by viral pathogens is ever changing and growing (1). Breakthroughs in the field of metagenomics had far-reaching effects on the identification of emerging viral pathogens and on the recognition that an increasing number of diseases that were once attributed to unknown causes are actually caused by infectious agents (1). Paraplegia is an impairment of motor or sensory functions of the lower extremities. Although it can be caused by spinal cord injury, nontraumatic paraplegia also should be considered, particularly in a tropical environment; tuberculosis and schistosomiasis may play a role, but in many cases, no firm diagnosis can be made (2). In this study, cerebrospinal fluid (CSF) and serum samples were obtained from 58 patients from Malawi who had paraplegia of unknown etiology and were studied for the presence of known or unknown viruses by using a metagenomics approach.