Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA - Vol. 19 No. 9 - September 2013 - Emerging Infectious Disease journal - CDC
Table of Contents
Volume 19, Number 9–September 2013
Volume 19, Number 9—September 2013
CME ACTIVITY
Mumps Postexposure Prophylaxis with a Third Dose of Measles-Mumps-Rubella Vaccine, Orange County, New York, USA
Abstract
Although the measles-mumps-rubella (MMR) vaccine is not recommended for mumps postexposure prophylaxis (PEP), data on its effectiveness are limited. During the 2009–2010 mumps outbreak in the northeastern United States, we assessed effectiveness of PEP with a third dose of MMR vaccine among contacts in Orthodox Jewish households who were given a third dose within 5 days of mumps onset in the household’s index patient. We compared mumps attack rates between persons who received a third MMR dose during the first incubation period after onset in the index patient and 2-dose vaccinated persons who had not. Twenty-eight (11.7%) of 239 eligible household members received a third MMR dose as PEP. Mumps attack rates were 0% among third-dose recipients versus 5.2% among 2-dose recipients without PEP (p = 0.57). Although a third MMR dose administered as PEP did not have a significant effect, it may offer some benefits in specific outbreak contexts.During 2009–2010, a large mumps outbreak affected 3,502 persons in the Orthodox Jewish community in the northeastern United States. Students, from elementary school through college, had 2,370 (67.7%) cases; of these case-patients, 85% had received the recommended 2 doses of MMR vaccine (8). Yeshivas (i.e., private, traditional Jewish schools with extended school days) and households characterized by large families, typical in the Orthodox Jewish community, were the primary settings for mumps transmission (8). The objective of this study was to assess secondary mumps attack rates among Orthodox Jewish household contacts in Orange County, New York, who received PEP with a third dose of MMR vaccine within 5 days of mumps introduction into a household by a family member, and compare them with household contacts of persons who had received 2 previous MMR doses and did not receive PEP.
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