Future Health Applications of Genomics: Priorities for Communication, Behavioral, and Social Sciences Research

Future Health Applications of Genomics: Priorities for Communication, Behavioral, and Social Sciences Research

• Colleen M. McBride, PhD^{a, ,} ,
• Deborah Bowen, PhD^d,
• Lawrence C. Brody, PhD^b,
• Celeste M. Condit, PhD^e,
• Robert T. Croyle, PhD^c,
• Marta Gwinn, MD^f,
• Muin J. Khoury, MD, PhD^f,
• Laura M. Koehly, PhD^a,
• Bruce R. Korf, MD, PhD^g,
• Theresa M. Marteau, PhD^h,
• Kenneth McLeroy, PhDⁱ,
• Kevin Patrick, MD, MS^j,
• Thomas W. Valente, PhD^k

• ^a Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland
• ^b Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland
• ^c Division of Cancer Control, Prevention, and Screening, National Cancer Institute, Bethesda, Maryland
• ^d Department of Social and Behavioral Sciences, Boston University, Boston, Massachusetts
• ^e Department of Speech Communication, University of Georgia, Athens
• ^f Office of Public Health Genomics, CDC, Atlanta, Georgia
• ^g Department of Genetics, University of Alabama, Tuscaloosa, Alabama
• ^h Department of Psychology, Kings College London, London, United Kingdom
• ⁱ Department of Social and Behavioral Health, Texas A&M Health Sciences Center, College Station, Texas
• ^j Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California
• ^k Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California

• http://dx.doi.org/10.1016/j.amepre.2010.01.027, How to Cite or Link Using DOI

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Abstract

Despite the quickening momentum of genomic discovery, the communication, behavioral, and social sciences research needed for translating this discovery into public health applications has lagged behind. The National Human Genome Research Institute held a 2-day workshop in October 2008 convening an interdisciplinary group of scientists to recommend forward-looking priorities for translational research. This research agenda would be designed to redress the top three risk factors (tobacco use, poor diet, and physical inactivity) that contribute to the four major chronic diseases (heart disease, type 2 diabetes, lung disease, and many cancers) and account for half of all deaths worldwide. Three priority research areas were identified: (1) improving the public's genetic literacy in order to enhance consumer skills; (2) gauging whether genomic information improves risk communication and adoption of healthier behaviors more than current approaches; and (3) exploring whether genomic discovery in concert with emerging technologies can elucidate new behavioral intervention targets. Important crosscutting themes also were identified, including the need to: (1) anticipate directions of genomic discovery; (2) take an agnostic scientific perspective in framing research questions asking whether genomic discovery adds value to other health promotion efforts; and (3) consider multiple levels of influence and systems that contribute to important public health problems. The priorities and themes offer a framework for a variety of stakeholders, including those who develop priorities for research funding, interdisciplinary teams engaged in genomics research, and policymakers grappling with how to use the products born of genomics research to address public health challenges.