EGAPP Initiative: Value of an Honest Broker in Genomic Medicine

Genomics|Update|Current

EGAPP Initiative: Value of an Honest Broker in Genomic Medicine

The EGAPP Initiative: Lessons learned
EGAPP Working Group, Genetics in Medicine, Aug 8

The EGAPP Working Group was established by CDC in 2005 to support the development of a systematic process for assessing the available evidence regarding the validity and utility of rapidly emerging genetic tests for clinical practice.
EGAPP methods update 2013
Veenstra et al., Genetics in Medicine (2012)

EGAPP approach to binning whole genome sequence information: a novel approach and pilot results.  [PDF 656.44 KB]
Goddard K et al., Genetics in Medicine 2013
Guidelines for guideline developers: a systematic review of grading systems for medical tests. Implementation Science 2013. EGAPP ranked highest on methodologic characteristics
Breaking a vicious cycle.
Hayes DF, et al. Sci Transl Med. 2013 Jul 31;5(196):196cm6.
"We recommend that FDA adopts the EGAPP definitions [endorsed by the National Cancer Institute (NCI) and IOM] of analytical and clinical validity and clinical utility…"