Online NowStructure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA
Gao, Patel, and colleagues
Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation
Nikolaus Pfanner and colleagues explain the import and folding of β-barrel proteins in the mitochondrial outer membrane. Two translocases are found to facilitate import by forming a supercomplex that mediates the ordered assembly of β-barrel proteins.
Featured Article free
Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat
Timothy Aitman and colleagues present the complete sequence and evolutionary analysis of 27 laboratory rat strains.
In this interview, Dr. Aitman describes how their in-depth analysis of variants and disease loci explain why rats continue to be excellent models for comparative genomic studies for the study of human diseases such as hypertension and diabetes among others.
Leading Edge Featured Article free
Defining PluripotencyStatistical Mechanics of Pluripotency
In this Essay, Ihor Lemischka and Ben MacArthur make a case for why single-cell-level analyses make it difficult to define the pluripotent state and how pluripotency itself is a statistical property of stem cell populations.
Ihor Lemischka and Ben MacArthur
From Shrinking Fat to Growing MusclesIn this month's Cell Podcast, we learn:
» How energy-burning brown fat could possibly be used to treat obesity, with Antonio Vidal-Puig (0:00) (Trends in Pharmacological Sciences)
» How sleeping muscle stem cells might be awakened to fight aging, with Thomas Rando (9:42) (Cell Reports)
» Plus, sample a selection of the hottest new papers from Cell Press (19:30)
Music for the podcast includes "TinyJazz" (axjack) / CC BY 3.0.
You can listen directly by clicking on the player above. For a complete list of Cell Press podcasts, you can subscribe via iTunes or view the archive.
Cell PaperClip from July 18th
Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes
Karen Steel describes a new resource of more than 900 new mutant mice lines and a multifaceted phenotypic screening platform.
In this interview, Dr. Steel highlights the insights that the resource has brought in unanticipated pleiotropies, widespread effects of haploinsufficiency, possible new disease models, and potential functions for unstudied genes.
The Nucleus portals are enhanced content collections that focus on specific biological processes or techniques. Each Nucleus contains unique elements, but all incorporate a relevant selection of Cell Press content, including reviews, primary articles, webinars, image galleries, and Symposia information.