June 3, 2013

Guideline Title

Clinical policy: use of intravenous tPA for the management of acute ischemic stroke in the emergency department.

Bibliographic Source(s)

Edlow JA, Smith EE, Stead LG, Gronseth G, Messe SR, Jagoda AS, Wears RL, Decker WW, American College of Emergency Physicians, American Academy of Neurology. Clinical policy: use of intravenous tPA for the management of acute ischemic stroke in the emergency department. Ann Emerg Med. 2013 Feb;61(2):225-43. [46 references] PubMed External Web Site Policy

Guideline Status

This is the current release of the guideline.

Clinical Policy: Use of intravenous tPA for th... [Ann Emerg Med. 2013] - PubMed - NCBI

2013 Feb;61(2):225-43. doi: 10.1016/j.annemergmed.2012.11.005.

Clinical Policy: Use of intravenous tPA for the management of acute ischemic stroke in the emergency department.

American College of Emergency Physicians; American Academy of Neurology.

Collaborators (10)

Abstract

This policy was developed by a joint writing panel of the American College of Emergency Physicians and the American Academy of Neurology. The panel reviewed the literature to derive evidence-based recommendations to help clinicians answer the following critical questions: (1) Is intravenous tissue plasminogen activator (tPA) safe and effective for acute ischemic stroke patients if given within 3 hours of symptom onset? (2) Is intravenous tPA safe and effective for acute ischemic stroke patients treated between 3 to 4.5 hours after symptom onset? Evidence was graded and recommendations were given based on the strength of the available data in the medical literature.