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Transmission and Maintenance Cycle of Bartonella quintana among Rhesus Macaques, China - Vol. 19 No. 2 - February 2013 - Emerging Infectious Disease journal - CDC

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Transmission and Maintenance Cycle of Bartonella quintana among Rhesus Macaques, China - Vol. 19 No. 2 - February 2013 - Emerging Infectious Disease journal - CDC

Georges de La Tour (1593‒1652) La Femme à la puce (The Flea Catcher) (1638) Oil on canvas (90 cm × 120 cm) Musée Lorrain, Nancy. Photo P. Mignot

Transmission and Maintenance Cycle of Bartonella quintana among Rhesus Macaques, China

The Study

Conclusions

Acknowledgments

References

Figure 1

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Technical Appendix [256 KB - 7 pages]

Suggested Citation

Hao Li, Wei Liu, Guang-Zhou Zhang, Zhao-Zeng Sun, Jie-Ying Bai, Bao-Gui Jiang, Yao-Yun Zhang, Xiao-Guang Zhao, Hong Yang, Guang Tian, Yu-Chuan Li, Lin Zeng, Michael Kosoy, and Wu-Chun Cao

Author affiliations: Author affiliations: State Key Laboratory of Pathogen and Biosecurity�?"Beijing Institute of Microbiology and Epidemiology, Beijing, People�?(tm)s Republic of China (H. Li, W. Liu, B.-G. Jiang, Y.-Y. Zhang, X.-G. Zhao, H. Yang, G. Tian, Y.-C. Li, W.-C. Cao); Academy of Military Medical Sciences Laboratory Animal Center, Beijing (G.-Z. Zhang, Z.-Z. Sun, J.-Y. Bai, L. Zeng); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (M. Kosoy)

Abstract

We detected Bartonella quintana in 48.6% of captive rhesus macaques from an animal facility in Beijing, China. Prevalence of infection increased over the period of observation. Our findings suggest that macaques may serve as reservoir hosts for B. quintana and that Pedicinus obtusus lice might act as efficient vectors.

Bartonella quintana is a vector-transmitted, hemotropic, and extremely fastidious gram-negative bacterium. Infection with B. quintana has been recognized to cause a broad spectrum of disease, including trench fever, chronic bacteremia, endocarditis, and bacillary angiomatosis (1�?"4). Humans are the primary reservoir host for B. quintana, which, unlike most other Bartonella species, lacks an identified animal reservoir, although some recent reports have found B. quintana in dogs and in cynomolgus and rhesus macaques (5�?"7). Almost 60 years ago, rhesus macaques were able to be experimentally infected with B. quintana (8). However, nonhuman primates have not been shown to support long-term maintenance, multiplication, and transmission of this pathogen, all of which would be expected if these animals were to act as reservoir species. Observations of monkey ectoparasites transmitting B. quintana between nonhuman primates or infecting humans have also not been reported.